{"doi":"10.21417/ga2021n","title":"Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans","abstract":"The Ad26.COV2.S vaccine1-3 has demonstrated clinical efficacy against symptomatic COVID-19, including against the B.1.351 variant that is partially resistant to neutralizing antibodies1. However, the immunogenicity of this vaccine in humans against SARS-CoV-2 variants of concern remains unclear. Here we report humoral and cellular immune responses from 20 Ad26.COV2.S vaccinated individuals from the COV1001 phase I-IIa clinical trial2 against the original SARS-CoV-2 strain WA1/2020 as well as against the B.1.1.7, CAL.20C, P.1 and B.1.351 variants of concern. Ad26.COV2.S induced median pseudovirus neutralizing antibody titres that were 5.0-fold and 3.3-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020 on day 71 after vaccination. Median binding antibody titres were 2.9-fold and 2.7-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020. Antibody-dependent cellular phagocytosis, complement deposition and natural killer cell activation responses were largely preserved against the B.1.351 variant. CD8 and CD4 T cell responses, including central and effector memory responses, were comparable among the WA1/2020, B.1.1.7, B.1.351, P.1 and CAL.20C variants. These data show that neutralizing antibody responses induced by Ad26.COV2.S were reduced against the B.1.351 and P.1 variants, but functional non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants. These findings have implications for vaccine protection against SARS-CoV-2 variants of concern.","journal":"immuneACCESS","year":2021,"id":213574,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":806135,"name":"J Yu","orcid":null,"position":1,"is_corresponding":false},{"id":805608,"name":"J Liu","orcid":"0009-0005-3742-037X","position":2,"is_corresponding":false},{"id":806136,"name":"A Chandrashekar","orcid":null,"position":3,"is_corresponding":false},{"id":806137,"name":"EN Borducchi","orcid":null,"position":4,"is_corresponding":false},{"id":806138,"name":"LT Tostanoski","orcid":null,"position":5,"is_corresponding":false},{"id":806139,"name":"K McMahan","orcid":null,"position":6,"is_corresponding":false},{"id":806140,"name":"C Jacob-Dolan","orcid":null,"position":7,"is_corresponding":false},{"id":806141,"name":"DR Martinez","orcid":null,"position":8,"is_corresponding":false},{"id":806142,"name":"A Chang","orcid":null,"position":9,"is_corresponding":false},{"id":806143,"name":"T Anioke","orcid":null,"position":10,"is_corresponding":false},{"id":806144,"name":"M Lifton","orcid":null,"position":11,"is_corresponding":false},{"id":806145,"name":"J Nkolola","orcid":null,"position":12,"is_corresponding":false},{"id":806146,"name":"KE Stephenson","orcid":null,"position":13,"is_corresponding":false},{"id":806147,"name":"C Atyeo","orcid":null,"position":14,"is_corresponding":false},{"id":806148,"name":"Seungeun Shin","orcid":null,"position":15,"is_corresponding":false},{"id":806149,"name":"P Fields","orcid":null,"position":16,"is_corresponding":false},{"id":559900,"name":"I Kaplan","orcid":null,"position":17,"is_corresponding":false},{"id":559919,"name":"H Robins","orcid":null,"position":18,"is_corresponding":false},{"id":806150,"name":"F Amanat","orcid":null,"position":19,"is_corresponding":false},{"id":806151,"name":"F Krammer","orcid":null,"position":20,"is_corresponding":false},{"id":806152,"name":"RS Baric","orcid":null,"position":21,"is_corresponding":false},{"id":806153,"name":"M Le Gars","orcid":null,"position":22,"is_corresponding":false},{"id":806154,"name":"J Sadoff","orcid":null,"position":23,"is_corresponding":false},{"id":806155,"name":"AM de Groot","orcid":null,"position":24,"is_corresponding":false},{"id":806156,"name":"D Heerwegh","orcid":null,"position":25,"is_corresponding":false},{"id":806157,"name":"F Struyf","orcid":null,"position":26,"is_corresponding":false},{"id":806158,"name":"M Douoguih","orcid":null,"position":27,"is_corresponding":false},{"id":806159,"name":"J van Hoof","orcid":null,"position":28,"is_corresponding":false},{"id":806160,"name":"H Schuitemaker","orcid":null,"position":29,"is_corresponding":false},{"id":106527,"name":"Dan H. 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