{"doi":"10.21417/adpt2020covid","title":"A large-scale database of T-cell receptor beta (TCRb) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2","abstract":"We describe the establishment and current content of the ImmuneCODE™ database, which includes hundreds of millions of T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with the SARS-CoV-2 virus, as well as over 160,000 high-confidence SARS-CoV-2-specific TCRs.This database is made freely available, and the data contained in it can be analyzed online or offline to assist with the global efforts to understand the immune response to the SARS-CoV-2 virus and develop new interventions. Use the "Open in Analyses" link now to explore the immune profile of ImmuneCODE subjects in immunoSEQ® Analyzer.Download the latest ImmuneCODE datasets here:Release 002 - 1,414 subjects exposed to or infected with the SARSCoV-2 virus: ImmuneCODE-Repertoires-002.tgz (23.8 GB)Release 002 - sample metadata: ImmuneCODE-Repertoire-Tags-002.2.tsv (572 KB)Release 002.1 - over 160,000 high-confidence SARS-CoV-2-specific TCRs: ImmuneCODE-MIRA-Release002.1.zip (3.7 MB)Release 002.2 - additional 72 subjects exposed to or infected with the SARSCoV-2 virus: ImmuneCODE-Repertoires-002.2.tgz (1 GB)Release 002.2 - sample metadata: ImmuneCODE-Repertoire-Tags-002.2.xlsx (352 KB)With the immunoSEQ® T-MAP™ COVID tools you can analyze and study the SARS-CoV-2-specific antigen and TCR data in the ImmuneCODE database. Use the "Open in Analyses" link above then choose "COVID Search Tool" from the Tools menu to explore the dataset.Use of the ImmuneCODE database is subject to Terms of Use. Full text of this manuscript is available at https://www.researchsquare.com/article/rs-51964/v1.The following files have been superceded but remain available for archival purposes:ImmuneCODE-MIRA-Release002.zip (3.0 MB)ImmuneCODE-Repertoire-Tags-002.tsv (514 KB)ImmuneCODE-Repertoire-Tags-002.xlsx (327 KB)","journal":"immuneACCESS","year":2020,"id":120827,"datarank":0.6937758422218219,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.348388078272715,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.348388078272715,"corpus_percentile":71.16887135452927,"corpus_rank":3728,"citation_count":9,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559897,"name":"M Vignali","orcid":null,"position":1,"is_corresponding":false},{"id":559898,"name":"M Klinger","orcid":null,"position":2,"is_corresponding":false},{"id":559899,"name":"J Dines","orcid":null,"position":3,"is_corresponding":false},{"id":559900,"name":"I Kaplan","orcid":null,"position":4,"is_corresponding":false},{"id":559901,"name":"T Craft","orcid":null,"position":5,"is_corresponding":false},{"id":559902,"name":"K Boland","orcid":null,"position":6,"is_corresponding":false},{"id":559903,"name":"M Pesesky","orcid":null,"position":7,"is_corresponding":false},{"id":559904,"name":"RM Gittelman","orcid":null,"position":8,"is_corresponding":false},{"id":559905,"name":"TM Snyder","orcid":null,"position":9,"is_corresponding":false},{"id":559906,"name":"CJ Gooley","orcid":null,"position":10,"is_corresponding":false},{"id":559907,"name":"S Semprini","orcid":null,"position":11,"is_corresponding":false},{"id":559908,"name":"C Cerchione","orcid":null,"position":12,"is_corresponding":false},{"id":559118,"name":"Mariano Mazza","orcid":"0000-0001-5259-1648","position":13,"is_corresponding":false},{"id":559909,"name":"OM Delmonte","orcid":null,"position":14,"is_corresponding":false},{"id":559910,"name":"K Dobbs","orcid":null,"position":15,"is_corresponding":false},{"id":559911,"name":"G Carreno-Tarragona","orcid":null,"position":16,"is_corresponding":false},{"id":559912,"name":"S Barrio","orcid":null,"position":17,"is_corresponding":false},{"id":559913,"name":"V Sambri","orcid":null,"position":18,"is_corresponding":false},{"id":559914,"name":"G Martinelli","orcid":null,"position":19,"is_corresponding":false},{"id":559915,"name":"Jason M. 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