{"doi":"10.21203/rs.2.21846/v1","title":"Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly","abstract":"Abstract Background: Mid-life obesity is related to increased risk for overall dementia and Alzheimer´s disease (AD) dementia. In the present work, we aimed to investigate the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) biomarkers of amyloid (Aβ 1-42) and tau-pathology (total-tau and p-tau) in healthy elderly. Methods: We selected healthy controls from ADNI2 with available CSF AD biomarkers and/or fluorodeoxyglucose (FDG) PET and 3T-MRI. Participants without follow-up or with significant weight loss were excluded from the analyses. Brain cortical thickness (Cth) was evaluated with Freesurfer software and FDG uptake was measured with a surface-based method using both SPM and Freesurfer softwares. We performed regression analyses between FDG uptake, CTh, CSF AD biomarkers levels and BMI and interaction analyses with age by obesity/overweight status. Results: We included 147 individuals (mean age 73.3 years, mean BMI 27.4 Kg/m 2 ). Higher BMI was related to less cortical thickness and higher glucose metabolism in brain areas not typically involved in AD (FWE<0.05), with little overlap between them. There was no association between BMI and any of the CSF core AD biomarkers. The relationship between age and brain metabolism was modified by overweight/obesity status, but not that of age and brain structure or core CSF AD biomarkers. Conclusions: Our data support that obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology in cognitively unimpaired elderly.","journal":"Research Square","year":2020,"id":121087,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":403868,"name":"Adriana Pané","orcid":"0000-0002-7810-1827","position":1,"is_corresponding":false},{"id":232592,"name":"Eduard Vilaplana","orcid":"0000-0002-1809-8435","position":2,"is_corresponding":false},{"id":232600,"name":"Víctor Montal","orcid":"0000-0002-5714-9282","position":3,"is_corresponding":false},{"id":304542,"name":"Alexandre Bejanin","orcid":"0000-0002-9958-0951","position":4,"is_corresponding":false},{"id":232595,"name":"Laura Videla","orcid":"0000-0002-9748-8465","position":5,"is_corresponding":false},{"id":232593,"name":"María Carmona‐Iragui","orcid":"0000-0001-6914-2339","position":6,"is_corresponding":false},{"id":232596,"name":"Isabel Barroeta","orcid":"0000-0003-2764-7923","position":7,"is_corresponding":false},{"id":403869,"name":"Ainitze Ibarzábal","orcid":"0000-0002-1220-6474","position":8,"is_corresponding":false},{"id":403870,"name":"Anna Casajoana","orcid":"0000-0003-2282-6965","position":9,"is_corresponding":false},{"id":232612,"name":"Daniel Alcolea","orcid":"0000-0002-3819-3245","position":10,"is_corresponding":false},{"id":232601,"name":"Sílvia Valldeneu","orcid":"0000-0003-3497-886X","position":11,"is_corresponding":false},{"id":232598,"name":"Miren Altuna","orcid":"0000-0001-9709-5314","position":12,"is_corresponding":false},{"id":403871,"name":"Ana de Hollanda","orcid":"0000-0001-9114-8614","position":13,"is_corresponding":false},{"id":251524,"name":"Josép Vidal","orcid":"0000-0002-4564-4518","position":14,"is_corresponding":false},{"id":403872,"name":"Emilio Ortega","orcid":"0000-0002-2217-8905","position":15,"is_corresponding":false},{"id":232608,"name":"Ricardo S. Osorio","orcid":"0000-0002-2735-9609","position":16,"is_corresponding":false},{"id":403873,"name":"Antonio Convit","orcid":"0000-0003-2201-2689","position":17,"is_corresponding":false},{"id":232614,"name":"Rafael Blesa","orcid":"0000-0003-4026-2884","position":18,"is_corresponding":false},{"id":27613,"name":"Alberto Lleó","orcid":"0000-0002-2568-5478","position":19,"is_corresponding":false},{"id":232591,"name":"Juan Fortea","orcid":"0000-0002-1340-638X","position":20,"is_corresponding":false},{"id":403874,"name":"Amanda Jiménez","orcid":"0000-0003-4967-1174","position":21,"is_corresponding":false},{"id":232599,"name":"Jordi Pegueroles","orcid":"0000-0002-3554-2446","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:14:42.734024Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}