{"doi":"10.21037/jgo-22-1067","title":"Hepatopancreatobiliary malignancies: time to treatment matters","abstract":"Background: Initiation of oncologic care is often delayed, yet little is known about delays in hepatopancreatobiliary (HPB) cancers or their impact. This retrospective cohort study describes trends in time to treatment initiation (TTI), assesses the association between TTI and survival, and identifies predictors of TTI in HPB cancers. Methods: The National Cancer Database was queried for patients with cancers of the pancreas, liver, and bile ducts between 2004 and 2017. Kaplan-Meier survival analysis and Cox regression were used to investigate the association between TTI and overall survival for each cancer type and stage. Multivariable regression identified factors associated with longer TTI. Results: stage IV, P<0.001), treatment with radiation only (β=+13.9 days, P<0.001), Black race (+4.6 days, P<0.001) and Hispanic ethnicity (+4.3 days, P<0.001). Conclusions: Some HPB cancer patients with longer time to definitive care experienced higher mortality than patients treated expeditiously, particularly in non-metastatic EHBD cancer. Black and Hispanic patients are at risk for delayed treatment. Further research into these associations is needed.","journal":"Journal of Gastrointestinal Oncology","year":2023,"id":353779,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6926,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1100933,"name":"Alexander E. Frey","orcid":null,"position":1,"is_corresponding":false},{"id":860409,"name":"Baylee Bakkila","orcid":"0000-0001-9506-1831","position":2,"is_corresponding":false},{"id":75965,"name":"Caroline H. Johnson","orcid":"0000-0002-5298-1299","position":3,"is_corresponding":false},{"id":403084,"name":"Robert D. Becher","orcid":"0000-0002-3717-865X","position":4,"is_corresponding":false},{"id":408730,"name":"Kevin G. Billingsley","orcid":"0000-0003-2217-5103","position":5,"is_corresponding":false},{"id":75966,"name":"Sajid Khan","orcid":"0000-0001-9897-6025","position":6,"is_corresponding":false},{"id":860410,"name":"Daniel Kerekes","orcid":"0000-0001-9467-1486","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"37201090","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}