{"doi":"10.21037/jgo-21-471","title":"Clinical and pathologic features correlated with rare favorable survival in patients with BRAFV600E mutated colorectal cancer","abstract":"Background: mutated metastatic CRC with favorable versus unfavorable outcomes have not been well annotated. Methods: mutated metastatic CRC evaluated at MD Anderson Cancer Center between 2005-2020 were reviewed. Patients with the shortest and longest metastatic survival (N=25 for each group) were compared. Associations between prognostic group and clinical/pathologic features were measured by odds ratio and for median survival by log-rank testing. Results: 16%, OR 4.1, 95% CI: 1.1-15.6, P=0.04) were associated with a favorable prognosis. Durable responses to MAPK-targeted therapies and immunotherapy were noted in the favorable group. Conclusions: mutated metastatic CRC, it is possible that few may achieve exceptionally favorable survival.","journal":"Journal of Gastrointestinal Oncology","year":2022,"id":290021,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":590669,"name":"Bryan K. Kee","orcid":"0000-0001-5553-2213","position":1,"is_corresponding":false},{"id":274184,"name":"Michael J. Overman","orcid":"0000-0001-5377-135X","position":2,"is_corresponding":false},{"id":274183,"name":"Arvind Dasari","orcid":"0000-0001-5271-9744","position":3,"is_corresponding":false},{"id":264370,"name":"Kanwal Raghav","orcid":"0000-0003-1311-4173","position":4,"is_corresponding":false},{"id":461070,"name":"Benny Johnson","orcid":"0000-0003-3683-8115","position":5,"is_corresponding":false},{"id":901932,"name":"Christine M. Parseghian","orcid":"0000-0002-2047-097X","position":6,"is_corresponding":false},{"id":395090,"name":"Robert A. Wolff","orcid":"0000-0002-6614-1610","position":7,"is_corresponding":false},{"id":347710,"name":"Naveen Garg","orcid":"0000-0002-0321-2813","position":8,"is_corresponding":false},{"id":332456,"name":"Cathy Eng","orcid":"0000-0003-2335-0612","position":9,"is_corresponding":false},{"id":241627,"name":"Scott Kopetz","orcid":"0000-0001-9647-3416","position":10,"is_corresponding":false},{"id":461072,"name":"Van K. Morris","orcid":"0000-0002-4911-2252","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:26.667578Z","pmid":"35557581","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}