{"doi":"10.21037/atm.2019.09.101","title":"Association between TIM-3 polymorphisms and cancer risk: a meta-analysis","abstract":"<h4>Background</h4>Single nucleotide polymorphisms (SNPs) of T-cell immunoglobulin- and mucin-domain-containing molecule 3 (<i>TIM-3</i>) were reported to individually associate with cancer risk. To further verify its correlation with human cancers, we evaluated the association of <i>TIM-3</i> polymorphisms and the risk of cancer.<h4>Methods</h4>Data were collected from electronic databases. Two reviewers independently selected studies, extracted data and assessed quality of the studies. Data were meta-analyzed using the STATA 13.0 software. Crude odd ratio (OR) and 95% confidence interval was used to estimate the association between <i>TIM-3</i> polymorphism and cancer susceptibility.<h4>Results</h4>All eligible case-control studies included a total of 4,852 participants (2,229 cases and 2,623 controls). The meta-analysis showed that <i>TIM-3</i> SNPs (-1516G/T, -574G/T, +4259T/G, and haplotypes) were significantly associated with an increased risk of susceptibility toward all cancers. The subgroup analyses based on cancer types showed that <i>TIM-3</i> -1516G/T SNP was only associated with an increased risk in developing cancers in the digestive system or in hospital-based populations. Moreover, the <i>TIM-3</i> -574G/T SNP was associated with an increased cancer risk in the digestive system or other systems, while <i>TIM-3</i> +4259T/G SNP was only associated with an increased cancer risk in hospital-based populations. Among the four haplotypes observed (GGT, TGT, GGG, and GTT), The GGG haplotype showed an increase in the odds of cancer by 2.614-fold (OR 2.614; 95% CI: 1.756-3.893) compared with the GGT haplotype.<h4>Conclusions</h4><i>TIM-3</i> SNPs (-1516G/T, -574G/T, +4259T/G and the four haplotypes) were associated with an increased risk of developing human cancers.","journal":"Annals of Translational Medicine","year":2019,"id":3468,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.22,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-10-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":33951,"name":"Cheng Yuan","orcid":null,"position":1,"is_corresponding":false},{"id":33953,"name":"Xinsheng Gu","orcid":"0000-0002-7884-3679","position":2,"is_corresponding":false},{"id":36219,"name":"Qiuju Chen","orcid":"0000-0001-7635-4401","position":3,"is_corresponding":false},{"id":33956,"name":"Dong Huang","orcid":"0000-0002-9448-4397","position":4,"is_corresponding":false},{"id":30887,"name":"Alexandra P. Lewis","orcid":"0000-0002-6195-4786","position":5,"is_corresponding":false},{"id":33950,"name":"Min Sun","orcid":"0000-0001-5883-0363","position":6,"is_corresponding":false},{"id":33957,"name":"Yuan Cheng","orcid":"0000-0002-0226-614X","position":7,"is_corresponding":false},{"id":36218,"name":"Hongyan Fang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}