{"doi":"10.21037/atm-21-5170","title":"Quantitative susceptibility mapping to evaluate brain iron deposition and its correlation with physiological parameters in hypertensive patients","abstract":null,"journal":"Annals of Translational Medicine","year":2021,"id":634222,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":912530,"name":"Dayong Jin","orcid":"0000-0003-1046-2666","position":1,"is_corresponding":false},{"id":1644760,"name":"Yinhu Zhu","orcid":null,"position":2,"is_corresponding":false},{"id":133172,"name":"Liyao Liu","orcid":null,"position":3,"is_corresponding":false},{"id":1644761,"name":"Yanqiang Qiao","orcid":null,"position":4,"is_corresponding":false},{"id":1644762,"name":"Yifan Qian","orcid":null,"position":5,"is_corresponding":false},{"id":1644763,"name":"Juan Tian","orcid":null,"position":6,"is_corresponding":false},{"id":1644764,"name":"Boyuan Jiang","orcid":null,"position":7,"is_corresponding":false},{"id":1644765,"name":"Chunkai Hou","orcid":null,"position":8,"is_corresponding":false},{"id":1644766,"name":"Jigang Geng","orcid":null,"position":9,"is_corresponding":false},{"id":1644767,"name":"Xiaoshi Li","orcid":null,"position":10,"is_corresponding":false},{"id":566026,"name":"Xiaohua Gao","orcid":"0000-0003-4308-6126","position":11,"is_corresponding":false},{"id":1644768,"name":"Yongli Ma","orcid":null,"position":12,"is_corresponding":false},{"id":885937,"name":"Shaoyu Wang","orcid":"0000-0002-1323-1655","position":13,"is_corresponding":false},{"id":1644769,"name":"Jianhai Zong","orcid":null,"position":14,"is_corresponding":false},{"id":1178593,"name":"Yue Qin","orcid":"0000-0002-5650-0149","position":15,"is_corresponding":false},{"id":801787,"name":"Xin Li","orcid":"0000-0002-8779-125X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantitative susceptibility mapping to evaluate brain iron deposition and its correlation with physiological parameters in hypertensive patients","abstract":"BACKGROUND: Regional excessive iron overload is pernicious to motor functions and cognitive functioning of the brain. The aim of this research was to utilize quantitative susceptibility mapping (QSM) to inspect brain iron accumulation in patients with hypertension (HP), and to evaluate whether it is correlated with physiological parameters. METHODS: Thirty-one HP and 31 age- and sex-matched healthy controls (HC) were included. All participants underwent brain magnetic resonance imaging (MRI), and QSM data were obtained. Differences in brain iron deposition in deep gray matter nuclei of participants were compared between HP and HC. The correlations between iron deposition, body mass index (BMI), maximum systolic blood pressure (SBP), and diastolic blood pressure (DBP) were analyzed. RESULTS: The HP group showed increased susceptibility values in the caudate nucleus (CA), putamen (PU), globus pallidus (GP), and dorsal thalamus (TH), compared with the HC group. There was a significant positive correlation between BMI and the susceptibility values in the dentate nucleus (DN); the maximum SBP and DBP were positively correlated with magnetic susceptibility of the CA, PU, GP, and TH, respectively. CONCLUSIONS: These results are indicative of the role of overload brain iron in deep brain gray matter nuclei in HP and suggest that HP is associated with excess brain iron in certain deep gray matter regions.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34790788","pmcid":"PMC8576670","openalex_id":"https://openalex.org/W3210647978","authors":[],"funders":[],"total_grants":0,"fwci":0.7033,"citation_percentile":0.70944618,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://atm.amegroups.com/article/viewFile/81901/pdf","host_type":"journal"},{"url":"https://atm.amegroups.com/article/viewFile/81901/pdf","host_type":"publisher"},{"url":"https://atm.amegroups.com/article/download/81901/pdf","host_type":"publisher"},{"url":"https://doi.org/10.21037/atm-21-5170","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34790788","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8576670","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8576670","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8576670?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Advanced MRI Techniques and Applications","Blood Pressure and Hypertension Studies","Iron Metabolism and Disorders"],"mesh_terms":[],"keywords":["Quantitative susceptibility mapping","Putamen","Globus pallidus","Dentate nucleus","Caudate nucleus","Internal medicine","Magnetic resonance imaging","Thalamus","Blood pressure","Endocrinology","Medicine","Nuclear magnetic resonance","Cardiology","Chemistry","Neuroscience","Basal ganglia","Psychology","Central nervous system","Cerebellum","Radiology","Hypertensive","Magnetic resonance imaging (MRI)","Iron Deposition","Deep Gray Matter","Quantitative Susceptibility Mapping (Qsm)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:20:43.525214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}