{"doi":"10.20944/preprints202510.0665.v1","title":"Biological Regulation of HIF-1a and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease","abstract":"Hypoxia, or lack of adequate oxygen saturation, activates a vast repertoire of vascular responses to increase cell survival and proliferation, driven primarily by activation of oxygen-sensing hypoxia-inducible factors (HIFs). Key hypoxia mediator HIF-1 alpha is capable of driving vascular restructuring in response to low oxygen tension and oxygen-independent signaling pathways, and thus serves as a promising therapeutic modulator for ischemic cardiovascular diseases such as peripheral artery disease and coronary artery disease. In this review, we discuss oxygen-dependent and oxygen-independent mechanisms of HIF-1 alpha regulation, the HIF protein family’s role in vessel collateralization, and translational efforts seeking to exploit HIF-1 alpha’s key role in hypoxia signaling for the purpose of therapeutic development of clinical treatments for ischemic cardiovascular disease.","journal":"Preprints.org","year":2025,"id":577523,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1374149,"name":"Patrick J. Bosco","orcid":null,"position":1,"is_corresponding":false},{"id":1373473,"name":"Anne-Isabelle S. Reme","orcid":"0000-0003-4080-7151","position":2,"is_corresponding":false},{"id":864133,"name":"Yulexi Y. Ortiz","orcid":null,"position":3,"is_corresponding":false},{"id":1373474,"name":"Daniela Alexandra Ramos","orcid":"0000-0001-6711-1811","position":4,"is_corresponding":false},{"id":1374150,"name":"Katherine Gomez","orcid":null,"position":5,"is_corresponding":false},{"id":1183635,"name":"Bao‐Ngoc Nguyen","orcid":null,"position":6,"is_corresponding":false},{"id":783435,"name":"Arash Bornak","orcid":"0000-0003-2847-0613","position":7,"is_corresponding":false},{"id":452718,"name":"Zhaojun Liu","orcid":"0000-0002-2301-0768","position":8,"is_corresponding":false},{"id":275494,"name":"Omaida C. Velázquez","orcid":"0000-0003-0841-0525","position":9,"is_corresponding":false},{"id":1374148,"name":"E. A. Carmichael","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:04.622308Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}