{"doi":"10.20944/preprints202502.1422.v1","title":"<span style=\"mso-bidi-font-weight: bold;\">SR-FTIR Biomolecular Characterization of the Hippocampus: the Role of Tenascin C in Adult Neurogenesis in the Subgranular Zone<span style=\"mso-bookmark: _Hlk188612129;\"><span style=\"mso-ansi-language: SR-LATN-RS; mso-bidi-font-weight: bold;\">","abstract":"To better understand adult neurogenesis, the biomolecular specificity of the subgranular zone should be investigated in comparison to other layers of the hippocampus. Adult neurogenesis occurs at a reduced rate in adulthood compared to the period of development, but it can be increased with exposure to enriched environment. This can be used to investigate the regulatory role of molecules present in the extracellular matrix, such as tenascin C. This study using Synchrotron radiation Fourier Transform Infrared spectroscopy (SR-FTIR) shows that the differences between the hippocampal layers in adolescence are maintained as subtle and significant in adulthood. Moreover, we have detected biomolecular changes that accompany the process of neurogenesis under the influence of enriched environment, while these effects are lacking in mice with a gene ablation for tenascin C.","journal":"Preprints.org","year":2025,"id":562329,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8409,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1464669,"name":"Andrej Korenić","orcid":"0000-0001-9476-7445","position":1,"is_corresponding":false},{"id":1188772,"name":"Vera Stamenković","orcid":null,"position":2,"is_corresponding":false},{"id":1464670,"name":"Tanja Dučić","orcid":"0000-0003-2389-3887","position":3,"is_corresponding":false},{"id":416177,"name":"Pavle R. Anđjus","orcid":"0000-0002-8468-8513","position":4,"is_corresponding":false},{"id":1465001,"name":"Milena Korenić","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:56:05.550545Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}