{"doi":"10.20944/preprints202306.0286.v1","title":"People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope","abstract":"We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T cell, viral load, HIV-1 genotype, class I HLA genotype, CCR5 polymorphism, and IFN-γ producing cells from a cohort of 37 people living with HIV-1 (PLWH) (viremic controllers, were compared those on antiretroviral therapy (ART) from two sites in São Paulo, Brazil. Half the PLWH (51.4%) were classified as viremic controllers (Controller group - CG), compared to 48.6% were on ART. As expected, controllers showed baseline higher levels of CD4+ T cells and nadir compared to those under ART, confirming the ability of HIV-1 controllers to preserve these cells even in the absence of ART. IFN-γ-producing cells showed greater magnitude to the HIV peptides Gag in controllers (p<0.03). Our results demonstrated that HLA protective alleles are associated with strong production of IFN-γ to Gag, Nef and RT epitopes in people living with HIV controllers.","journal":"Preprints.org","year":2023,"id":399701,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8866,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1175765,"name":"Laís Teodoro da Silva","orcid":"0000-0001-8542-802X","position":1,"is_corresponding":false},{"id":1176125,"name":"Gustavo Ferminie Hildebrando","orcid":null,"position":2,"is_corresponding":false},{"id":1175766,"name":"Paula Ordonhez Rigato","orcid":"0000-0002-4416-3544","position":3,"is_corresponding":false},{"id":1175767,"name":"Luís Fernando de Macedo Brígido","orcid":"0000-0002-1022-7837","position":4,"is_corresponding":false},{"id":1175768,"name":"Marcello Mihailenko Chaves Magri","orcid":"0000-0001-7996-8265","position":5,"is_corresponding":false},{"id":1175769,"name":"Mariana Amélia Monteiro","orcid":"0000-0002-6015-9924","position":6,"is_corresponding":false},{"id":1175770,"name":"Tatiane Assone","orcid":"0000-0003-0993-4523","position":7,"is_corresponding":false},{"id":1175771,"name":"Alberto José da Silva Duarte","orcid":"0000-0002-8707-4904","position":8,"is_corresponding":false},{"id":1175772,"name":"Jorge Casseb","orcid":"0000-0002-4553-2559","position":9,"is_corresponding":false},{"id":1175764,"name":"Bosco Christiano Maciel da Silva","orcid":"0000-0002-3883-7178","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:19:56.084411Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}