{"doi":"10.20944/preprints202207.0409.v1","title":"MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans","abstract":"Background: We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Methods: Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. Results: miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Conclusion: Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.","journal":"Preprints.org","year":2022,"id":303922,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":584447,"name":"Anusha Angajala","orcid":"0000-0002-6838-2346","position":1,"is_corresponding":false},{"id":920936,"name":"Aliyu Muhammad","orcid":"0000-0002-4167-7793","position":2,"is_corresponding":false},{"id":965293,"name":"Hughley Raymond","orcid":null,"position":3,"is_corresponding":false},{"id":996784,"name":"Shakir Md Ahmed","orcid":null,"position":4,"is_corresponding":false},{"id":965294,"name":"Saadia Haleema","orcid":null,"position":5,"is_corresponding":false},{"id":964803,"name":"Monira Haque","orcid":"0000-0003-2475-3202","position":6,"is_corresponding":false},{"id":917599,"name":"Honghe Wang","orcid":"0000-0002-1401-4476","position":7,"is_corresponding":false},{"id":565989,"name":"Rachel Martini","orcid":"0000-0002-8921-0041","position":8,"is_corresponding":false},{"id":965295,"name":"Balasubramanian Karanam","orcid":null,"position":9,"is_corresponding":false},{"id":964804,"name":"Andrea G. Kahn","orcid":"0000-0003-3905-0390","position":10,"is_corresponding":false},{"id":817112,"name":"Deepa Bedi","orcid":"0000-0003-4403-2680","position":11,"is_corresponding":false},{"id":20886,"name":"Melissa B. Davis","orcid":"0000-0002-6124-6923","position":12,"is_corresponding":false},{"id":964805,"name":"Ming Tan","orcid":"0000-0001-6565-699X","position":13,"is_corresponding":false},{"id":566597,"name":"Windy Dean‐Colomb","orcid":null,"position":14,"is_corresponding":false},{"id":210849,"name":"Clayton C. Yates","orcid":"0000-0001-5420-9852","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:32:28.468841Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}