{"doi":"10.20944/preprints202111.0009.v1","title":"A Randomized, Open-Label Study to Assess Efficacy of Weekly Assumption of Cholecalciferol Versus Calcifediol in Older Patients With Hypovitaminosis D","abstract":"The aim of this single-center, open-label, non-controlled randomized study was to evaluate which formulation of vitamin D between cholecalciferol and calcifediol is most effective in the treatment of hypovitaminosis D in older adults. Demographic characteristics, clinical history and comprehensive geriatric assessment were recorded at admission. Eligible patients randomly received an equivalent vitamin D supplement either with cholecalciferol or calcifediol from hospital admission to three months after discharge. Among the 140 older patients included (mean age 83±6.6, 57.8% females), 69 received cholecalciferol and 71 calcifediol. The mean plasma values of 25OH-Vitamin D3 found at the enrollment were 16.8 ± 9.9 ng/mL in patients receiving cholecalciferol and 18.8 ± 13.3 ng/mL in those treated with calcifediol (p =0.31). At the 3-month follow up, the mean concentration of 25OH-Vitamin D3 was significantly higher in patients treated with calcifediol than in patients treated with cholecalciferol (respectively, 30.7 ± 8.4 vs 45.4 ± 9.8 ng/mL, p <0.001). Supplementation with cholecalciferol or calcifediol results in both cases effective in reaching optimal circulating values of 25OH-VitaminD3 in the older patients suffering from hypovitaminosis D. However, supplementation with calcifediol led to average circulating values of 25OH- VitaminD3 significantly higher (over 50%) than those obtained with cholecalciferol.","journal":"Preprints.org","year":null,"id":44645,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":209867,"name":"Valeria Calsolaro","orcid":null,"position":1,"is_corresponding":false},{"id":209868,"name":"Filippo Niccolai","orcid":null,"position":2,"is_corresponding":false},{"id":209869,"name":"Alessia Maria Calabrese","orcid":null,"position":3,"is_corresponding":false},{"id":209870,"name":"Riccardo Franchi","orcid":null,"position":4,"is_corresponding":false},{"id":209871,"name":"Sara Rogani","orcid":null,"position":5,"is_corresponding":false},{"id":209872,"name":"Giulia Coppini","orcid":null,"position":6,"is_corresponding":false},{"id":209873,"name":"Virginia Morelli","orcid":null,"position":7,"is_corresponding":false},{"id":209874,"name":"Nadia Caraccio","orcid":null,"position":8,"is_corresponding":false},{"id":209875,"name":"Fabio Monzani","orcid":"0000-0003-1676-098X","position":9,"is_corresponding":false},{"id":209866,"name":"Chukwuma Okoye","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21062823","pmcid":null,"openalex_id":"https://openalex.org/W3207997346","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.preprints.org/manuscript/202111.0009/v1/download","host_type":"repository"},{"url":"https://www.preprints.org/manuscript/202111.0009/v1/download","host_type":"repository"},{"url":"https://doi.org/10.20944/preprints202111.0009.v1","host_type":"repository"}],"fields_of_study":["Vitamin D Research Studies","Pancreatitis Pathology and Treatment","Cystic Fibrosis Research Advances"],"mesh_terms":[],"keywords":["Calcifediol","Cholecalciferol","Vitamin D and neurology","Medicine","Hypovitaminosis","Internal medicine","Quality of Life Research","Vitamin","vitamin D deficiency","Gastroenterology","Endocrinology","Pathology","Public health"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-01T18:14:32.315178Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}