{"doi":"10.20944/preprints202012.0501.v1","title":"Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family","abstract":"<jats:p>A growing body of evidence continues to demonstrate the vital roles that zinc and its transporters play on human health. The solute carrier (SLC) 30 and 39 families, with ten and fourteen members, respectively, control zinc transport in cells. TMEM163, a recently characterized zinc transporter, has similar characteristics in both structure and function to the SLC30 family. This review examines recent data that reveal TMEM163 to be a zinc efflux transporter and a new member of the cation diffusion facilitator (CDF) family of mammalian zinc transporter (ZNT) proteins. It also discusses reports that implicate TMEM163 in various human diseases.</jats:p>","journal":null,"year":null,"id":598582,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":447477,"name":"Math P. Cuajungco","orcid":"0000-0003-0749-9564","position":1,"is_corresponding":false},{"id":950689,"name":"Daniel J. 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It also discusses reports that implicate TMEM163 in various human diseases.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W3117819670","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"2R15NS101594-02","title":"DISSECTING THE ROLE OF TMEM163 PROTEIN IN CELLS"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.preprints.org/manuscript/202012.0501/v1/download","host_type":"repository"},{"url":"https://www.preprints.org/manuscript/202012.0501/v1/download","host_type":"repository"},{"url":"https://doi.org/10.20944/preprints202012.0501.v1","host_type":"repository"},{"url":"https://doi.org/10.3390/biomedicines9020220","host_type":""},{"url":"https://www.mdpi.com/2227-9059/9/2/220/pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/33670071","host_type":""},{"url":"http://dx.doi.org/10.3390/biomedicines9020220","host_type":""},{"url":"https://doaj.org/article/d7bd0a8c7c3942749a321c161fe06a14","host_type":""},{"url":"https://dx.doi.org/10.20944/preprints202012.0501.v1","host_type":""},{"url":"https://dx.doi.org/10.3390/biomedicines9020220","host_type":""}],"fields_of_study":["Trace Elements in Health","Drug Transport and Resistance Mechanisms","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Efflux","Transporter","Zinc","Major facilitator superfamily","Solute carrier family","Family member","Transmembrane protein","Protein family","Facilitator","Function (biology)","Transport protein","Biology","Biochemistry","Chemistry","Cell biology","Medicine","Gene","Receptor","Psychology","SV31","zinc transporter","QH301-705.5","Biochemistry and Molecular Biology","Biology and Life Sciences","cation diffusion facilitator","Review","Biology (General)"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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