{"doi":"10.20944/preprints202012.0209.v1","title":"Contrasting Epidemiology and Genetic Variation of <em>Plasmodium vivax</em> Infecting Duffy Negatives across Africa","abstract":"Recent studies indicated that Plasmodium vivax can infect Duffy-negative individuals, but the varied diagnostic and methodological approaches have limited our ability to characterize P. vivax across Africa. Here, we utilized a standardized approach to compare epidemiological and genetic attributes of P. vivax from Botswana, Ethiopia, and Sudan, where Duffy-positive and Duffy-negative individuals coexist. Among 1,215 febrile patients, the proportions of Duffy negativity range from 20-36% in East Africa to 84% in Southern Africa. Considerable differences were observed in P. vivax prevalence among Duffy-negative populations ranging from averaged 9.2% in Sudan to 86% in Botswana. P. vivax parasite density in Duffy-negative infections is significantly lower than in Duffy-positive infections. Phylogenetic analyses of 229 PvDBP sequences indicated that Duffy-negative P. vivax were not monophyletic but occurred in multiple well-supported clades, suggesting independent origins. Duffy-negative Africans are clearly not resistant to P. vivax and the public health significance should no longer be neglected.","journal":"Preprints.org","year":2020,"id":131970,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9373,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586878,"name":"Gianluca Russo","orcid":"0000-0002-8764-7389","position":1,"is_corresponding":false},{"id":586879,"name":"Kareen Pestana","orcid":"0000-0001-9775-5378","position":2,"is_corresponding":false},{"id":476981,"name":"Daniel Kepple","orcid":"0000-0003-0566-3623","position":3,"is_corresponding":false},{"id":587425,"name":"Beka Raya Abargero","orcid":null,"position":4,"is_corresponding":false},{"id":586880,"name":"Ghyslaine Bruna Djeunang Dongho","orcid":"0000-0002-7810-9095","position":5,"is_corresponding":false},{"id":478053,"name":"Karthigayan Gunalan","orcid":null,"position":6,"is_corresponding":false},{"id":333594,"name":"Louis H. Miller","orcid":"0000-0002-3709-0092","position":7,"is_corresponding":false},{"id":487115,"name":"Muzamil Mahdi Abdel Hamid","orcid":"0000-0002-6157-4388","position":8,"is_corresponding":false},{"id":269981,"name":"Delenasaw Yewhalaw","orcid":"0000-0002-2907-9360","position":9,"is_corresponding":false},{"id":586881,"name":"Giacomo Maria Paganotti","orcid":"0000-0002-0751-0682","position":10,"is_corresponding":false},{"id":337677,"name":"Eugenia Lo","orcid":"0000-0002-5631-4709","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:16:07.542484Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}