{"doi":"10.20900/immunometab20220001","title":"A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity","abstract":"Abstract T cells rapidly convert their cellular metabolic requirements upon activation, switching to a highly glycolytic program to satisfy their increasingly complex energy needs. Fundamental metabolic differences have been established for the development of Foxp3 + T regulatory (Treg) cells versus T H 17 cells, alterations of which can drive disease. T H 17 cell dysregulation is a driver of autoimmunity and chronic inflammation, contributing to pathogenesis in diseases such as multiple sclerosis. A recent paper published in Cell by Wagner, et al. combined scRNA-seq and metabolic mapping data to interrogate potential metabolic modulators of T H 17 cell pathogenicity. This Compass to T H 17 cell metabolism highlights the polyamine pathway as a critical regulator of T H 17/Treg cell function, signifying its potential as a therapeutic target.","journal":"Immunometabolism","year":2021,"id":210103,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":282824,"name":"Sarah A. Mosure","orcid":"0000-0003-4477-5396","position":1,"is_corresponding":false},{"id":238455,"name":"Laura A. Solt","orcid":"0000-0001-8807-0342","position":2,"is_corresponding":false},{"id":798687,"name":"Adrianna N. Wilson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T23:52:08.869117Z","pmid":"34900348","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}