{"doi":"10.20517/jtgg.2021.26","title":"Roles of interacting stress related genes in lifespan regulation: insights for translating experimental findings to humans","abstract":"AIM: Experimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating cell survival can play a crucial role in cell response to nutritional stressors. However, it is unclear whether the interplay among corresponding genes also plays a role in human health and lifespan. METHODS: (SIPRS). RESULTS: genes that were associated with survival 85+ compared to survival between ages 75 and 85 in the total sample (males and females combined) and in females only. This may reflect sex differences in genetic regulation of the human lifespan. Highly statistically significant associations of SIPRS [constructed for the rs16970024 (GCN2/EIF2AK4) and rs697221 (CHOP/DDIT3)] with survival in both sexes also been found in this study. CONCLUSION: Identifying associations of the genetic interactions with human survival is an important step in translating the knowledge from experimental to human aging research. Significant associations of multiple SNPxSNP interactions in ISR genes with survival to the oldest old age that have been found in this study, can help uncover mechanisms of multifactorial regulation of human lifespan and its heterogeneity.","journal":"Journal of Translational Genetics and Genomics","year":2021,"id":205386,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9615,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":446984,"name":"Deqing Wu","orcid":"0000-0003-3047-7996","position":1,"is_corresponding":false},{"id":280707,"name":"Konstantin G. Arbeev","orcid":"0000-0002-4195-7832","position":2,"is_corresponding":false},{"id":429753,"name":"Arseniy Yashkin","orcid":"0000-0002-1185-148X","position":3,"is_corresponding":false},{"id":284481,"name":"Igor Akushevich","orcid":"0000-0003-3471-7846","position":4,"is_corresponding":false},{"id":283256,"name":"Olivia Bagley","orcid":null,"position":5,"is_corresponding":false},{"id":286911,"name":"Matt Duan","orcid":null,"position":6,"is_corresponding":false},{"id":264268,"name":"Svetlana Ukraintseva","orcid":"0000-0002-0079-5494","position":7,"is_corresponding":false},{"id":264271,"name":"Anatoliy I. Yashin","orcid":"0000-0003-4262-8894","position":0,"is_corresponding":true}],"reference_count":214,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:51:33.996102Z","pmid":"34825130","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}