{"doi":"10.20517/jca.2022.13","title":"Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications","abstract":"Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. Recently, we reported that the nucleus-mitochondria positive feedback loop formed by p90 ribosomal S6 kinase (p90RSK) and phosphorylation of S496 on ERK5 (a unique member of the mitogen-activated protein kinase family that is not only a kinase but also a transcriptional co-activator) were vital signaling events that played crucial roles in linking mitochondrial dysfunction, nuclear telomere dysfunction, persistent SASP induction, and atherosclerosis. In this review, we will discuss the role of NAD+ depletion in instigating SASP and its downstream signaling and regulatory mechanisms that lead to the premature onset of atherosclerotic cardiovascular diseases in cancer survivors.","journal":"The Journal of Cardiovascular Aging","year":2022,"id":275456,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":664674,"name":"Elizabeth A. Olmsted‐Davis","orcid":"0000-0001-9457-1848","position":1,"is_corresponding":false},{"id":381192,"name":"Anita Deswal","orcid":"0000-0002-6147-9591","position":2,"is_corresponding":false},{"id":945532,"name":"Minh Tho Ho Nguyen","orcid":null,"position":3,"is_corresponding":false},{"id":827838,"name":"Efstratios Koutroumpakis","orcid":"0000-0002-6757-6480","position":4,"is_corresponding":false},{"id":945533,"name":"Nicholas L. Palaskas","orcid":null,"position":5,"is_corresponding":false},{"id":236019,"name":"Steven H. Lin","orcid":"0000-0003-4411-0634","position":6,"is_corresponding":false},{"id":664671,"name":"Sivareddy Kotla","orcid":"0000-0001-7516-7647","position":7,"is_corresponding":false},{"id":447287,"name":"Cielito C. Reyes‐Gibby","orcid":"0000-0003-4500-6476","position":8,"is_corresponding":false},{"id":434206,"name":"Sai‐Ching J. Yeung","orcid":"0000-0001-5170-0822","position":9,"is_corresponding":false},{"id":673648,"name":"Syed Wamique Yusuf","orcid":"0000-0002-6966-6068","position":10,"is_corresponding":false},{"id":641028,"name":"Momoko Yoshimoto","orcid":"0000-0002-7272-6682","position":11,"is_corresponding":false},{"id":818352,"name":"Michihiro Kobayashi","orcid":"0000-0001-6065-6026","position":12,"is_corresponding":false},{"id":51217,"name":"Bing Yu","orcid":"0000-0003-4818-1077","position":13,"is_corresponding":false},{"id":278745,"name":"Keri Schadler","orcid":"0000-0002-1675-0514","position":14,"is_corresponding":false},{"id":488011,"name":"Joerg Herrmann","orcid":"0000-0001-6675-4559","position":15,"is_corresponding":false},{"id":276970,"name":"John P. Cooke","orcid":"0000-0003-0033-9138","position":16,"is_corresponding":false},{"id":331424,"name":"Abhishek Jain","orcid":"0000-0003-2235-5139","position":17,"is_corresponding":false},{"id":256584,"name":"Eduardo N. Chini","orcid":"0000-0003-1555-4834","position":18,"is_corresponding":false},{"id":664675,"name":"Nhat-Tu Le","orcid":"0000-0002-7664-2160","position":19,"is_corresponding":false},{"id":449040,"name":"Jun‐ichi Abe","orcid":"0000-0001-7439-7774","position":20,"is_corresponding":false},{"id":314200,"name":"Priyanka Banerjee","orcid":"0000-0001-6040-2675","position":0,"is_corresponding":true}],"reference_count":214,"raw_metadata":null,"created_at":"2026-07-19T00:28:21.971703Z","pmid":"35801078","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}