{"doi":"10.20517/jca.2021.21","title":"Systemic delivery of large-scale manufactured Wharton’s Jelly mesenchymal stem cell-derived extracellular vesicles improves cardiac function after myocardial infarction","abstract":"INTRODUCTION: Cardiovascular disease and myocardial infarction are leading causes of morbidity and mortality in aged populations. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are under evaluation as a therapeutic option for the treatment of myocardial infarction. AIM: This study aimed to develop a large-scale manufacturing procedure to harvest clinical-grade EVs required for the translation of EVs to the clinic. METHODS AND RESULTS: The systemic delivery of EV products improved cardiac function following myocardial infarctions as indicated by a significant improvement in ejection fraction as well as parameters of cardiac performance, afterload, contractility and lusitropy. CONCLUSION: These findings have important implications for scale-up strategies of EVs and will facilitate clinical trials for their clinical evaluation.","journal":"The Journal of Cardiovascular Aging","year":2021,"id":179861,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569760,"name":"Rosemeire M. Kanashiro‐Takeuchi","orcid":"0000-0002-7305-9172","position":1,"is_corresponding":false},{"id":569761,"name":"Lauro M Takeuchi","orcid":"0000-0002-4517-9548","position":2,"is_corresponding":false},{"id":397419,"name":"Shathiyah Kulandavelu","orcid":"0000-0003-0966-7613","position":3,"is_corresponding":false},{"id":585428,"name":"Yee‐Shuan Lee","orcid":"0000-0003-0250-6542","position":4,"is_corresponding":false},{"id":408638,"name":"Wayne Balkan","orcid":"0000-0003-0405-0489","position":5,"is_corresponding":false},{"id":397425,"name":"Karen Young","orcid":"0000-0002-3921-8467","position":6,"is_corresponding":false},{"id":88819,"name":"Joshua M. Hare","orcid":"0000-0002-7751-5032","position":7,"is_corresponding":false},{"id":408636,"name":"Aisha Khan","orcid":"0000-0001-7409-9208","position":8,"is_corresponding":false},{"id":582570,"name":"Michael A. Bellio","orcid":"0000-0002-2793-8619","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:47:53.089578Z","pmid":"35112111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}