{"doi":"10.20517/2394-4722.2023.34","title":"Role of epithelial-mesenchymal transition factor SNAI1 and its targets in ovarian cancer aggressiveness","abstract":"<jats:p>Ovarian cancer remains the most lethal gynecologic malignancy in the USA. For over twenty years, epithelial-mesenchymal transition (EMT) has been characterized extensively in development and disease. The dysregulation of this process in cancer has been identified as a mechanism by which epithelial tumors become more aggressive, allowing them to survive and invade distant tissues. This occurs in part due to the increased expression of the EMT transcription factor, SNAI1 (Snail). In the case of epithelial ovarian cancer, Snail has been shown to contribute to cancer invasion, stemness, chemoresistance, and metabolic changes. Thus, in this review, we focus on summarizing current findings on the role of EMT (specifically, factors downstream of Snail) in determining ovarian cancer aggressiveness.</jats:p>","journal":"Journal of Cancer Metastasis and Treatment","year":2023,"id":671061,"datarank":0.664853132108909,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.20817476645039543,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.20817476645039543,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":18,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1753027,"name":"Ashlyn Conant","orcid":null,"position":1,"is_corresponding":false},{"id":1753029,"name":"Casey Curow","orcid":null,"position":2,"is_corresponding":false},{"id":1753031,"name":"Audrey Alexander","orcid":null,"position":3,"is_corresponding":false},{"id":1753033,"name":"Yevgeniya Ioffe","orcid":null,"position":4,"is_corresponding":false},{"id":1753034,"name":"Juli J. 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In the case of epithelial ovarian cancer, Snail has been shown to contribute to cancer invasion, stemness, chemoresistance, and metabolic changes. Thus, in this review, we focus on summarizing current findings on the role of EMT (specifically, factors downstream of Snail) in determining ovarian cancer aggressiveness.</jats:p>","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38009093","pmcid":"PMC10673625","openalex_id":"https://openalex.org/W4382600892","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R25 GM060507","title":null}],"total_grants":1,"fwci":2.3015,"citation_percentile":0.9015879,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":8},{"year":2025,"count":5},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.20517/2394-4722.2023.34","host_type":"journal"},{"url":"https://doi.org/10.20517/2394-4722.2023.34","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38009093","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10673625","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10673625/pdf/nihms-1921727.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10673625","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10673625?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer Cells and Metastasis"],"mesh_terms":[],"keywords":["SNAI1","Epithelial–mesenchymal transition","Snail","Ovarian cancer","Cancer research","Transcription factor","Biology","Malignancy","Cancer","Metastasis","Oncology","Medicine","Internal medicine","Gene","Epithelial-mesenchymal Transition","Chemoresistance","Cancer Aggressiveness","Cancer Invasion","Cancer Stemness"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T01:11:25.331252Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}