{"doi":"10.20411/pai.v5i1.365","title":"Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop","abstract":"People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff organized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.","journal":"Pathogens and Immunity","year":2020,"id":56857,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":95191,"name":"Beth D. Jamieson","orcid":"0000-0003-1206-3853","position":1,"is_corresponding":false},{"id":295811,"name":"Ronald G. Collman","orcid":"0000-0002-0508-3701","position":2,"is_corresponding":false},{"id":262177,"name":"Michael M. Lederman","orcid":"0000-0001-9247-8025","position":3,"is_corresponding":false},{"id":282163,"name":"Tricia H. Burdo","orcid":"0000-0002-4224-7381","position":4,"is_corresponding":false},{"id":71691,"name":"Steven G. Deeks","orcid":"0000-0001-6371-747X","position":5,"is_corresponding":false},{"id":295812,"name":"Dirk P. Dittmer","orcid":"0000-0003-4968-5656","position":6,"is_corresponding":false},{"id":69464,"name":"Howard S. Fox","orcid":"0000-0003-2032-374X","position":7,"is_corresponding":false},{"id":295813,"name":"Nicholas Funderburg","orcid":"0000-0003-3113-1217","position":8,"is_corresponding":false},{"id":295814,"name":"Savita Pahwa","orcid":"0000-0002-4470-4216","position":9,"is_corresponding":false},{"id":295815,"name":"Ivona Pandrea","orcid":"0000-0002-4041-2961","position":10,"is_corresponding":false},{"id":295816,"name":"Cara C. Wilson","orcid":"0000-0003-4399-2225","position":11,"is_corresponding":false},{"id":239685,"name":"Peter W. Hunt","orcid":"0000-0002-4571-4870","position":12,"is_corresponding":false},{"id":18100,"name":"Dana Gabuzda","orcid":"0000-0002-4964-5083","position":0,"is_corresponding":true}],"reference_count":153,"raw_metadata":null,"created_at":"2026-07-18T21:06:09.605575Z","pmid":"32856008","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}