{"doi":"10.19080/crdoj.2020.12.555849","title":"The Influence of Heat on Appetite-Regulating Adipokines","abstract":"Leptin has been established as an energy-controlling hormone because of its role in activating the JAK-STAT3 pathway. Exercising in the heat (1-hour of cycling @60% VO2max in 33C) has induced reductions in leptin. However, in order to better understand the influence of environmental temperature, independent of exercise, a fasted resting investigation is needed. This investigation explored the impact of environmental temperature (33 vs. 20C) on adipose-derived appetite-regulating hormones (leptin and adiponectin) and energy expenditure. Ten college-aged males (275y, 8613kg, and 1834cm) completed two randomized, resting trials in the Heat (HT, 33C) and in Room Temperature (RT, 20C). Blood draws were taken pre-intervention and 3h post-intervention for analysis of leptin and adiponectin. Oxygen consumption was measured at 1-, 2-, and 3-h timepoints. HT trial temperatures were greater than RT for core (37.170.08 vs. 36.890.08C, p=0.002) and skin (37.590.10 vs. 32.650.48C; p<0.001). Oxygen consumption was higher in HT than RT during the 2 nd (4.370.14 vs. 4.130.15 ml/kg/min, p=0.037) and 3 rd (4.950.26 vs. 4.280.19 ml/kg/min, p=0.002) hours. Fasting leptin concentrations in RT decreased to a greater extent than in HT (mean SEM; -2.050.83 vs. -0.890.74 ng/ml; p=0.032); however, after adjustment for plasma volume shifts (-7.54.2%) the interaction disappeared (mean SEM; -1.791.72 vs. -0.890.74 ng/ml; p=0.068). Heat stress increased oxygen kinetics and attenuated the normal reduction in leptin over time, effectively slowing the rise in hunger (maintaining satiety) within a fasted state. These data may have implications for appetite control, weight management, and nutritional interventions during heat exposure.","journal":"Current Research in Diabetes & Obesity Journal","year":2020,"id":129319,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":580544,"name":"Dustin Slivka","orcid":"0000-0001-7337-3770","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T23:15:45.920615Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}