{"doi":"10.18865/ed.34.2.103","title":"Intracranial Volume Is Driven by Both Genetics and Early Life Exposures: The SOL-INCA-MRI Study","abstract":"Intracranial volume (ICV) reflects maximal brain development and is associated with later-life cognitive abilities. We quantified ICV among first- and second-generation Hispanic and Latino adults from the Study of Latinos-Investigation of Cognitive Aging – MRI (SOL-INCA-MRI), estimated ICV heritability, and tested its associations with previously reported genetic variants, both individually and as a genetic risk score (GRS). We also estimated the association of ICV with early life environmental measures: nativity or age of immigration and parental education. The estimated heritability of ICV was 19% (95% CI, 0.1%-56%) in n=1781 unrelated SOL-INCA-MRI individuals. Four of 10 tested genetic variants were associated with ICV and an increase of 1 SD of the ICV-GRS was associated with an increase of 10.37 cm3 in the ICV (95% CI, 5.29-15.45). Compared to being born in the continental United States, immigrating to the United States at age 11 years or older was associated with 24 cm3 smaller ICV (95% CI, −39.97 to −8.06). Compared to both parents having less than high-school education, at least 1 parent completing high-school education was associated with 15.4 cm3 greater ICV (95% CI, 4.46-26.39). These data confirm the importance of early life health on brain development.","journal":"Ethnicity & Disease","year":2024,"id":461107,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9084,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":303805,"name":"Einat Granot‐Hershkovitz","orcid":"0000-0003-0645-2713","position":1,"is_corresponding":false},{"id":303806,"name":"Wassim Tarraf","orcid":"0000-0001-8888-7918","position":2,"is_corresponding":false},{"id":1096072,"name":"Paola Filigrana","orcid":"0000-0002-8297-3943","position":3,"is_corresponding":false},{"id":91398,"name":"Carmen R. Isasi","orcid":"0000-0003-2700-9593","position":4,"is_corresponding":false},{"id":325857,"name":"Shakira F. Suglia","orcid":"0000-0002-5634-9290","position":5,"is_corresponding":false},{"id":440310,"name":"Robert C. Kaplan","orcid":"0000-0003-3271-801X","position":6,"is_corresponding":false},{"id":236910,"name":"Kent D. Taylor","orcid":"0000-0002-2756-4370","position":7,"is_corresponding":false},{"id":37779,"name":"Martha L. Daviglus","orcid":"0000-0002-6791-8727","position":8,"is_corresponding":false},{"id":466167,"name":"Fernando D. Testai","orcid":"0000-0002-7355-4915","position":9,"is_corresponding":false},{"id":303811,"name":"Donglin Zeng","orcid":"0000-0003-0843-9280","position":10,"is_corresponding":false},{"id":577698,"name":"Jianwen Cai","orcid":"0000-0003-1813-0594","position":11,"is_corresponding":false},{"id":17640,"name":"Myriam Fornage","orcid":"0000-0003-0677-8158","position":12,"is_corresponding":false},{"id":303812,"name":"Hector M. González","orcid":"0000-0003-4867-7902","position":13,"is_corresponding":false},{"id":277082,"name":"Charles DeCarli","orcid":"0000-0003-1914-2693","position":14,"is_corresponding":false},{"id":17004,"name":"Tamar Sofer","orcid":"0000-0001-8520-8860","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:04:12.271488Z","pmid":"38973806","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}