{"doi":"10.18632/oncotarget.27991","title":"Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study","abstract":"// Anjali Gupta 1 , 2 , Taofik Oyekunle 2 , Omolola Salako 3 , Adetola Daramola 3 , Olusegun Alatise 4 , Gabriel Ogun 5 , Adewale Adeniyi 6 , April Deveaux 2 , Veeral Saraiya 7 , Allison Hall 8 , Omobolaji Ayandipo 5 , Thomas Olajide 3 , Olalekan Olasehinde 4 , Olukayode Arowolo 4 , Adewale Adisa 4 , Oludolapo Afuwape 5 , Aralola Olusanya 5 , Aderemi Adegoke 9 , Trygve O. Tollefsbol 10 , Donna Arnett 11 , Michael J. Muehlbauer 12 , Christopher B. Newgard 12 , H3 Africa Kidney Research Network 13 and Tomi Akinyemiju 2 , 14 , 15 1 Trinity College of Arts and Sciences, Duke University, Durham, NC, USA 2 Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC, USA 3 College of Medicine & Lagos University Teaching Hospital, University of Lagos, Lagos State, Nigeria 4 Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria 5 University College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria 6 Federal Medical Center, Abeokuta, Ogun State, Nigeria 7 Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA 8 Department of Pathology, School of Medicine, Duke University, Durham, NC, USA 9 Our Lady of Apostle Catholic Hospital, Ibadan, Oyo State, Nigeria 10 Department of Biology, College of Arts and Sciences, University of Alabama at Birmingham, AL, USA 11 College of Public Health, University of Kentucky, Lexington, KY, USA 12 Duke Molecular Physiology Institute, Duke University, Durham, NC, USA 13 Department of Internal Medicine, School of Medicine, University of Kansas Medical Center, Kansas City, KS, USA 14 Duke Cancer Institute, School of Medicine, Duke University, Durham, NC, USA 15 Duke Global Health Institute, Duke University, Durham, NC, USA Correspondence to: Tomi Akinyemiju, email: tomi.akinyemiju@duke.edu Keywords: C-reactive protein; breast cancer; Nigeria; molecular subtype; menopausal status Received: May 14, 2021     Accepted: June 02, 2021     Published: June 22, 2021 Copyright: © 2021 Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Breast cancer (BC) in Nigeria is characterized by disproportionately aggressive molecular subtypes. C-reactive protein (CRP) is associated with risk and aggressiveness for several types of cancer. We examined the association of high-sensitivity CRP (hsCRP) with odds of BC by molecular subtype among Nigerian women. Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between hsCRP and odds of BC overall and by molecular subtype (luminal A, luminal B, HER2-enriched and triple-negative or TNBC). High hsCRP (> 3 mg/L) was observed in 57% of cases and 31% of controls and was associated with 4 times the odds of BC (aOR: 4.43; 95% CI: 2.56, 7.66) after adjusting for socio-demographic, reproductive, and clinical variables. This association persisted regardless of menopausal status and body mass index (BMI) category. High hsCRP was associated with increased odds of TNBC (aOR: 3.32; 95% CI: 1.07, 10.35), luminal A BC (aOR: 4.03; 95% CI: 1.29, 12.64), and HER2-enriched BC (aOR: 6.27; 95% CI: 1.69, 23.25). Future studies are necessary in this population to further evaluate a potential role for CRP as a predictive biomarker for BC.","journal":"Oncotarget","year":2021,"id":185221,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":327374,"name":"Taofik Oyekunle","orcid":null,"position":1,"is_corresponding":false},{"id":741260,"name":"Omolola Salako","orcid":"0000-0003-3165-8879","position":2,"is_corresponding":false},{"id":741261,"name":"Adetola Daramola","orcid":"0000-0002-8007-2455","position":3,"is_corresponding":false},{"id":514834,"name":"Olusegun Isaac Alatise","orcid":"0000-0002-0565-077X","position":4,"is_corresponding":false},{"id":741262,"name":"Gabriel Olabiyi Ogun","orcid":"0000-0001-8535-3240","position":5,"is_corresponding":false},{"id":741719,"name":"Adewale Adeniyi","orcid":null,"position":6,"is_corresponding":false},{"id":312440,"name":"April Deveaux","orcid":"0000-0002-1185-7750","position":7,"is_corresponding":false},{"id":600556,"name":"Veeral Saraiya","orcid":null,"position":8,"is_corresponding":false},{"id":371342,"name":"Allison Hall","orcid":"0000-0003-3413-603X","position":9,"is_corresponding":false},{"id":741263,"name":"Omobolaji Ayandipo","orcid":"0000-0002-6806-8015","position":10,"is_corresponding":false},{"id":741264,"name":"Thomas Olajide","orcid":"0000-0001-6125-2242","position":11,"is_corresponding":false},{"id":668951,"name":"Olalekan Olasehinde","orcid":"0000-0002-8706-0756","position":12,"is_corresponding":false},{"id":668950,"name":"Olukayode Arowolo","orcid":"0000-0002-2592-1119","position":13,"is_corresponding":false},{"id":741265,"name":"Adewale Adisa","orcid":"0000-0003-1927-3992","position":14,"is_corresponding":false},{"id":741720,"name":"Oludolapo Afuwape","orcid":null,"position":15,"is_corresponding":false},{"id":741721,"name":"Aralola Olusanya","orcid":null,"position":16,"is_corresponding":false},{"id":741722,"name":"Aderemi Adegoke","orcid":null,"position":17,"is_corresponding":false},{"id":295145,"name":"Trygve O. Tollefsbol","orcid":"0000-0002-0284-1511","position":18,"is_corresponding":false},{"id":24678,"name":"Donna K. Arnett","orcid":"0000-0003-2219-657X","position":19,"is_corresponding":false},{"id":88852,"name":"Michael J. Muehlbauer","orcid":"0000-0003-1501-0706","position":20,"is_corresponding":false},{"id":63769,"name":"Christopher B. Newgard","orcid":"0000-0002-1293-691X","position":21,"is_corresponding":false},{"id":48220,"name":"Tomi Akinyemiju","orcid":"0000-0002-1412-3234","position":22,"is_corresponding":false},{"id":741259,"name":"Anjali Gupta","orcid":"0000-0003-4470-4248","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:48:34.992499Z","pmid":"34194621","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}