{"doi":"10.18632/oncotarget.27555","title":"Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model","abstract":"// Gilseung Park 1 , * , Jessica Burroughs-Garcia 2 , * , Clay A. Foster 3 , * , Ameera Hasan 4 , Chiara Borga 2 and J. Kimble Frazer 1 , 2 , 4 1 Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA 2 Department of Pediatrics, Section of Pediatric Hematology-Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA 3 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA 4 Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA * These authors contributed equally to this work Correspondence to: J. Kimble Frazer, email: Kimble-Frazer@ouhsc.edu Keywords: acute lymphoblastic leukemia; ALL; zebrafish; lymphocyte; MYC Received: November 13, 2019     Accepted: March 19, 2020     Published: April 14, 2020 ABSTRACT Acute lymphoblastic leukemia (ALL) is the most common pediatric, and ninth most common adult, cancer. ALL can develop in either B or T lymphocytes, but B-lineage ALL (B-ALL) exceeds T-ALL clinically. As for other cancers, animal models allow study of the molecular mechanisms driving ALL. Several zebrafish ( Danio rerio ) T-ALL models have been reported, but until recently, robust D. rerio B-ALL models were not described. Then, D. rerio B-ALL was discovered in two related zebrafish transgenic lines; both were already known to develop T-ALL. Here, we report new B-ALL findings in one of these models, fish expressing transgenic human MYC ( hMYC ). We describe B-ALL incidence in a large cohort of hMYC fish, and show B-ALL in two new lines where T-ALL does not interfere with B-ALL detection. We also demonstrate B-ALL responses to steroid and radiation treatments, which effect ALL remissions, but are usually followed by prompt relapses. Finally, we report gene expression in zebrafish B lymphocytes and B-ALL, in both bulk samples and single B- and T-ALL cells. Using these gene expression profiles, we compare differences between the two new D. rerio B-ALL models, which are both driven by transgenic mammalian MYC oncoproteins. Collectively, these new data expand the utility of this new vertebrate B-ALL model.","journal":"Oncotarget","year":2020,"id":86850,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":337181,"name":"Jessica Burroughs-Garcìa","orcid":"0000-0002-9094-2370","position":1,"is_corresponding":false},{"id":416153,"name":"Clay A. Foster","orcid":"0000-0003-4549-0974","position":2,"is_corresponding":false},{"id":442222,"name":"Ameera Hasan","orcid":"0009-0001-8593-4835","position":3,"is_corresponding":false},{"id":442223,"name":"Chiara Borga","orcid":"0000-0003-0974-0323","position":4,"is_corresponding":false},{"id":442224,"name":"J. Kimble Frazer","orcid":"0000-0003-2936-2817","position":5,"is_corresponding":false},{"id":442221,"name":"Gilseung Park","orcid":"0000-0003-3605-8928","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32341750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}