{"doi":"10.18632/oncotarget.17459","title":"A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells","abstract":null,"journal":"Oncotarget","year":2017,"id":613637,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1498695,"name":"Young Joon Park","orcid":"0000-0003-0723-4136","position":1,"is_corresponding":false},{"id":15715,"name":"Nuri Oh","orcid":"0009-0000-1388-1650","position":2,"is_corresponding":false},{"id":1580985,"name":"Kyu Bum Kwack","orcid":null,"position":3,"is_corresponding":false},{"id":677975,"name":"Kyung-Soon Park","orcid":"0000-0002-5036-1803","position":4,"is_corresponding":false},{"id":1454592,"name":"Jae Yong Lee","orcid":"0000-0002-4967-911X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells","abstract":"// Jae Yong Lee 1 , Young Joon Park 1 , Nuri Oh 1 , Kyu Bum Kwack 1 and Kyung-Soon Park 1 1 Department of Biomedical Science, College of Life Science, CHA University, Seoul, Korea Correspondence to: Kyung-Soon Park, email: kspark@cha.ac.kr Keywords: estrogen receptor alpha, GATA3, FOXA1, ELL3, interleukin-20 Received: September 08, 2016 Accepted: April 15, 2017 Published: April 27, 2017 ABSTRACT Interleukin-20 ( IL-20 ) is a member of the IL-10 family. IL-20 expression is regulated by a transcription elongation factor, Ell3, in estrogen receptor-positive (ER(+)) breast cancer cells. In this study, we demonstrated that ER(α), GATA3 and FOXA1 form a transcriptional complex with Ell3 to regulate IL-20 expression in ER(+) breast cancer cells. We also determined that GATA3 and FOXA1 share a binding site with ER(α) in the interleukin-20 promoter. Furthermore, we found that FOXA1 represses IL-20 expression, whereas GATA3 and ER(α) activate it. In addition, we demonstrated that Ell3 associates with ER(α) to increase its binding affinity to the IL-20 promoter, which may prevent FOXA1 binding to the same region of this promoter. Our results expand upon the current understanding of the regulatory mechanism of IL-20 in cancer.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28514748","pmcid":"PMC5522103","openalex_id":"https://openalex.org/W2607688894","authors":[],"funders":[],"total_grants":0,"fwci":0.4984,"citation_percentile":0.59646044,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":3},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17459&path%5B%5D=55870","host_type":"journal"},{"url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17459&path%5B%5D=55870","host_type":"publisher"},{"url":"https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.17459","host_type":"publisher"},{"url":"https://doi.org/10.18632/oncotarget.17459","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28514748","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5522103","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5522103","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5522103?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Immune Cell Function and Interaction","Cancer Immunotherapy and Biomarkers","RNA modifications and cancer","Breast Neoplasms","Estrogen Receptor alpha","Female","GATA3 Transcription Factor","Gene Expression Regulation, Neoplastic","Hepatocyte Nuclear Factor 3-alpha","Humans","Interleukins","MCF-7 Cells","Transcriptional Elongation Factors"],"mesh_terms":["Breast Neoplasms","Female","Humans","Interleukins","Gene Expression Regulation, Neoplastic","Transcriptional Elongation Factors","Estrogen Receptor alpha","GATA3 Transcription Factor","Hepatocyte Nuclear Factor 3-alpha","MCF-7 Cells"],"keywords":["FOXA1","GATA3","Transcription factor","Estrogen receptor","Cancer research","Breast cancer","Estrogen receptor alpha","Biology","Cell biology","Chemistry","Molecular biology","Cancer","Gene","Genetics","Ell3","Interleukin-20"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T08:47:45.444228Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}