{"doi":"10.18632/oncotarget.10674","title":"UHRF1 suppression promotes cell differentiation and reduces inflammatory reaction in anaplastic thyroid cancer","abstract":null,"journal":"Oncotarget","year":2018,"id":654867,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1709207,"name":"Guo-He Lin","orcid":null,"position":1,"is_corresponding":false},{"id":602084,"name":"Bo Wang","orcid":"0000-0001-9998-9979","position":2,"is_corresponding":false},{"id":169204,"name":"Min Yan","orcid":null,"position":3,"is_corresponding":false},{"id":770484,"name":"Bin He","orcid":"0000-0001-6884-6166","position":4,"is_corresponding":false},{"id":830037,"name":"Wei Zhang","orcid":"0000-0002-3575-6225","position":5,"is_corresponding":false},{"id":1709208,"name":"An-Kui Yang","orcid":null,"position":6,"is_corresponding":false},{"id":1575290,"name":"Zi-Jie Long","orcid":null,"position":7,"is_corresponding":false},{"id":525127,"name":"Quentin Liu","orcid":"0000-0002-0999-9805","position":8,"is_corresponding":false},{"id":1709206,"name":"Bi-Cheng Wang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"UHRF1 suppression promotes cell differentiation and reduces inflammatory reaction in anaplastic thyroid cancer","abstract":"// Bi-Cheng Wang 1, * , Guo-He Lin 1, * , Bo Wang 2, * , Min Yan 1 , Bin He 1 , Wei Zhang 1 , An-Kui Yang 1 , Zi-Jie Long 3, 4 , Quentin Liu 1, 3, 4, 5 1 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China 2 Department of Medical Oncology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510700, China 3 Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China 4 Institute of Hematology, Sun Yat-sen University, Guangzhou, 510630, China 5 Institute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044, China * These authors have contributed equally to this work Correspondence to: Quentin Liu, email: liuq9@mail.sysu.edu.cn Zi-Jie Long, email: longzij@mail.sysu.edu.cn Keywords: UHRF1, anaplastic thyroid cancer, proliferation, differentiation, inflammatory reaction Received: January 09, 2016     Accepted: June 02, 2016     Epub: July 18, 2016     Published: August 10, 2018 ABSTRACT Anaplastic thyroid cancer (ATC), an undifferentiated subtype of thyroid cancer, is one of the most malignant endocrine cancer with low survival rate, and resistant to chemotherapy and radiation therapy. Here we found that UHRF1 was highly expressed in human ATC compared with normal tissue and papillary thyroid cancer (PTC). Knockdown of UHRF1 inhibited proliferation of ATC in vitro and in vivo . Consistently, overexpression of UHRF1 promoted the proliferation of thyroid cancer cells. Moreover, UHRF1 suppression induced differentiation of three-dimensional (3D) cultured ATC cells and down-regulated the expression of dedifferentiation marker (CD97). The stem cell markers (Sox2, Oct4 and Nanog) were suppressed simultaneously. In addition, UHRF1 knockdown reduced the transcription of cytokines (IL-8, TGF-α and TNF-α), which might relieve the inflammatory reaction in ATC patients. This study demonstrated a role of UHRF1 in ATC proliferation, dedifferentiation and inflammatory reaction, presenting UHRF1 as a potential target in ATC therapy.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30174788","pmcid":"PMC6112835","openalex_id":"https://openalex.org/W2501231653","authors":[],"funders":[{"funder_name":"NIAAA NIH HHS","grant_id":"U01 AA020926","title":null}],"total_grants":1,"fwci":0.4599,"citation_percentile":0.69464886,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10674&path%5B%5D=33793","host_type":"journal"},{"url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10674&path%5B%5D=33793","host_type":"publisher"},{"url":"https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.10674","host_type":"publisher"},{"url":"https://doi.org/10.18632/oncotarget.10674","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30174788","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6112835","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112835","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6112835","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6112835?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Thyroid Cancer Diagnosis and Treatment","RNA modifications and cancer","Cancer, Hypoxia, and Metabolism"],"mesh_terms":[],"keywords":["Anaplastic thyroid cancer","Thyroid cancer","Medicine","Internal medicine","Cancer","Cancer research","Oncology","Hematology","Differentiation","Proliferation","Inflammatory reaction","Uhrf1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T08:43:04.605422Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}