{"doi":"10.18632/oncoscience.412","title":"Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model","abstract":null,"journal":"Oncoscience","year":2018,"id":598926,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376492,"name":"Hope E. Burks","orcid":"0000-0002-2433-8423","position":1,"is_corresponding":false},{"id":376491,"name":"Steven Elliott","orcid":"0000-0003-1167-867X","position":2,"is_corresponding":false},{"id":488385,"name":"Van T. Hoang","orcid":"0000-0002-1561-0915","position":3,"is_corresponding":false},{"id":391120,"name":"Annie C. Bowles","orcid":"0000-0003-1924-8949","position":4,"is_corresponding":false},{"id":376493,"name":"Rachel A. Sabol","orcid":"0000-0002-0280-8818","position":5,"is_corresponding":false},{"id":282160,"name":"Bruce A. Bunnell","orcid":"0000-0001-6196-3722","position":6,"is_corresponding":false},{"id":706759,"name":"Elizabeth C. Martin","orcid":"0000-0002-1421-1963","position":7,"is_corresponding":false},{"id":376497,"name":"Matthew E. Burow","orcid":"0000-0002-0642-6630","position":8,"is_corresponding":false},{"id":1445162,"name":"Bridgette M. Collins-Burow","orcid":null,"position":9,"is_corresponding":false},{"id":376490,"name":"Margarite D. Matossian","orcid":"0000-0002-9527-1043","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model","abstract":"-low triple negative breast cancer (CL-TNBC) is a clinically aggressive molecular TNBC subtype characterized by a propensity to metastasize, recur and acquire chemoresistance. CL-TNBC has a diverse intra-and extracellular composition and microenvironment, and currently there are no clinically approved targeted therapies. Histone deacetylase inhibitors (HDACi) have been investigated as therapeutic agents targeting invasive TNBC phenotypes. However, further studies are required to evaluate HDAC inhibition in CL-TNBC. Here, we utilize a novel CL-TNBC patient-derived xenograft model to study the various and diverse therapeutic potential targets within CL-TNBC tumors. To evaluate effects of the pan-HDACi panobinostat on metastasis and the mesenchymal phenotype of CL-TNBC, we utilize immunohistochemistry staining and qRT-PCR in in vitro, ex vivo and in vivo studies. Further, we evaluate pan-HDAC inhibition on stem-like subpopulations using 3D mammosphere culture techniques and quantification. Finally, we show that pan-HDACi suppresses collagen expression in CL-TNBC. In this study, we provide evidence that pan-HDAC inhibition has effects on various components of the CL-TNBC subtype, and we demonstrate the potential of our novel CL-TNBC PDX model in therapeutic discovery research.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29854878","pmcid":"PMC5978446","openalex_id":"https://openalex.org/W2978126835","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01 CA125806","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA174785","title":null},{"funder_name":"NIH HHS","grant_id":"P51 OD011104","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"U54 GM104940","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01CA174785-04","title":"Kinase mediated suppression of metastasis in breast cancer"},{"funder_name":"National Institutes of Health","grant_id":"5R01CA125806-05","title":"MEK5-Erk5 in breast cancer resistance"}],"total_grants":6,"fwci":0.9022,"citation_percentile":0.74493468,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.oncoscience.us/article/412/pdf/","host_type":"journal"},{"url":"https://www.oncoscience.us/article/412/pdf/","host_type":"publisher"},{"url":"https://www.oncoscience.us/lookup/doi/10.18632/oncoscience.412","host_type":"publisher"},{"url":"https://doi.org/10.18632/oncoscience.412","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29854878","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5978446","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5978446","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5978446?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.18632/oncoscience.412","host_type":""},{"url":"https://dx.doi.org/10.18632/oncoscience.412","host_type":""}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Glioma Diagnosis and Treatment","Brain Metastases and Treatment","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Triple-negative breast cancer","Panobinostat","Cancer research","Breast cancer","In vivo","Histone deacetylase","Immunohistochemistry","Medicine","Chemistry","Cancer","Biology","Pathology","Internal medicine","Histone","Extracellular matrix","Histone deacetylase inhibitor","Claudin-low","Patient-derived Xenograft","Research Paper"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:25:46.652345Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}