{"doi":"10.18632/aging.206325","title":"L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice","abstract":"Contracting skeletal muscles secrete the metabolite L-β-aminoisobutyric acid (L-BAIBA), which when supplemented in the diet can mitigate disuse-induced musculoskeletal dysfunction. However, the effects of L-BAIBA supplementation alone and combined with exercise on cardiac and musculoskeletal properties are currently unknown. We hypothesized that exercise with L-BAIBA supplementation would promote greater cardiac and musculoskeletal benefits than exercise alone. To investigate this hypothesis, we subjected 12-month-old (as a model of middle-age) male C57BL6 mice to voluntary wheel running (VWR) with L-BAIBA (100mg/kg/day) (VWR+L-BAIBA), VWR alone, L-BAIBA alone, or none (CTRL) for three months. After the intervention, conscious electrocardiogram showed slightly prolonged QTc in VWR+L-BAIBA mice compared to CTRL (p<0.05). Soleus muscles from VWR+L-BAIBA, but not VWR, were larger, contracted more forcefully, and contained more slow-oxidative type I myofibers compared to CTRL (p<0.05). In EDL muscle, VWR but not VWR+L-BAIBA improved fatigue resistance and caffeine-induced recovery (p<0.05). In bone, VWR+L-BAIBA but not VWR showed lower bone marrow adiposity, higher trabecular thickness, and connectivity, smaller bone diameter and Moment of Inertia, but higher Modulus of Elasticity than CTRL (p<0.05), suggesting L-BAIBA delays aging-induced periosteal expansion due to better bone material qualities. These findings suggest a physiological interaction between exercise and L-BAIBA supplementation to improve soleus muscle and bone properties and reduce bone marrow adiposity.","journal":"Aging","year":2025,"id":528981,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":465741,"name":"Yukiko Kitase","orcid":"0000-0002-3139-0895","position":1,"is_corresponding":false},{"id":318219,"name":"Ganesh Thiagarajan","orcid":"0000-0001-5645-232X","position":2,"is_corresponding":false},{"id":490878,"name":"Mark Dallas","orcid":"0000-0002-5190-0522","position":3,"is_corresponding":false},{"id":968779,"name":"Yixia Xie","orcid":null,"position":4,"is_corresponding":false},{"id":335309,"name":"David S. Moore","orcid":"0000-0002-4280-2912","position":5,"is_corresponding":false},{"id":392535,"name":"Mark L. Johnson","orcid":"0000-0002-7762-8731","position":6,"is_corresponding":false},{"id":226479,"name":"Lynda F. Bonewald","orcid":"0000-0002-5536-9943","position":7,"is_corresponding":false},{"id":493761,"name":"Michael Wacker","orcid":"0000-0002-1768-562X","position":8,"is_corresponding":false},{"id":493759,"name":"Julian Vallejo","orcid":"0000-0002-6592-5931","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T02:50:52.565868Z","pmid":"41045489","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}