{"doi":"10.18632/aging.206311","title":"A protective role of SRC-1 against aging associated cognitive decline","abstract":"INTRODUCTION: Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator. METHODS: ), and performed promoter luciferase assays on S100A6. RESULTS: mice displayed early signs of contextual memory impairment at 6 months of age. Mechanistically, SRC-1 significantly promoted the expression S100A6. CONCLUSION: We identified a protective role of SRC1 against aging associated cognitive decline, potentially by promoting the expression of S100A6.","journal":"Aging","year":2025,"id":546415,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296401,"name":"Yongjie Yang","orcid":"0000-0002-2354-4727","position":1,"is_corresponding":false},{"id":784828,"name":"Jonathan C. Bean","orcid":"0000-0002-8007-2383","position":2,"is_corresponding":false},{"id":339387,"name":"Yang He","orcid":"0000-0002-7460-5649","position":3,"is_corresponding":false},{"id":473924,"name":"Hailan Liu","orcid":"0000-0001-5737-9240","position":4,"is_corresponding":false},{"id":1380321,"name":"Rambabu Majji","orcid":null,"position":5,"is_corresponding":false},{"id":651352,"name":"Liang Chen","orcid":"0000-0002-5562-350X","position":6,"is_corresponding":false},{"id":1438126,"name":"Nan Zhang","orcid":"0000-0002-6202-9349","position":7,"is_corresponding":false},{"id":296400,"name":"Meng Yu","orcid":"0000-0002-8007-3378","position":8,"is_corresponding":false},{"id":417767,"name":"Longlong Tu","orcid":"0000-0002-6955-6002","position":9,"is_corresponding":false},{"id":1258518,"name":"Qingzhuo Liu","orcid":"0009-0003-1243-2783","position":10,"is_corresponding":false},{"id":655031,"name":"Yue Deng","orcid":"0000-0001-8874-911X","position":11,"is_corresponding":false},{"id":331088,"name":"Kristie Conde","orcid":"0000-0002-9525-4606","position":12,"is_corresponding":false},{"id":1276652,"name":"Na Yin","orcid":"0000-0001-6026-2721","position":13,"is_corresponding":false},{"id":1068653,"name":"Mengjie Wang","orcid":"0000-0003-3637-4787","position":14,"is_corresponding":false},{"id":655845,"name":"Yongxiang Li","orcid":"0000-0001-7183-9485","position":15,"is_corresponding":false},{"id":456039,"name":"Junying Han","orcid":null,"position":16,"is_corresponding":false},{"id":1258521,"name":"Sanika V Jossy","orcid":"0009-0007-9619-7985","position":17,"is_corresponding":false},{"id":1259006,"name":"Megan E Burt","orcid":null,"position":18,"is_corresponding":false},{"id":288606,"name":"Hari Krishna Yalamanchili","orcid":"0000-0001-9892-3054","position":19,"is_corresponding":false},{"id":296398,"name":"Chunmei Wang","orcid":"0000-0001-8104-6892","position":20,"is_corresponding":false},{"id":417765,"name":"Hesong Liu","orcid":"0000-0003-3768-1463","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:53:32.285899Z","pmid":"40882002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}