{"doi":"10.18632/aging.205741","title":"The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats","abstract":"Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer's disease (AD). This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and impaired motor coordination at 12 months of age. Neither KD nor IKD improved performance compared to CD. At 12 months of age, TgF344-AD animals had elevated blood lipids. IKD reduced lipids to WT levels with KD further reducing cholesterol below WT levels. This study shows that at 8 or 12 months of age, KD or IKD intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids.","journal":"Aging","year":2024,"id":438201,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1248430,"name":"Zabrisky Roland","orcid":null,"position":1,"is_corresponding":false},{"id":323927,"name":"Anthony E. Valenzuela","orcid":"0000-0001-9507-355X","position":2,"is_corresponding":false},{"id":1248431,"name":"An B. Nguyen","orcid":null,"position":3,"is_corresponding":false},{"id":300153,"name":"Heui Hye Park","orcid":null,"position":4,"is_corresponding":false},{"id":1248432,"name":"Natalie Six","orcid":null,"position":5,"is_corresponding":false},{"id":1248026,"name":"İlknur Dursun","orcid":"0000-0001-7094-3336","position":6,"is_corresponding":false},{"id":442445,"name":"Kyoungmi Kim","orcid":"0000-0002-8661-7508","position":7,"is_corresponding":false},{"id":227733,"name":"Pamela J. Lein","orcid":"0000-0001-7665-7584","position":8,"is_corresponding":false},{"id":293325,"name":"Jon J. Ramsey","orcid":null,"position":9,"is_corresponding":false},{"id":525525,"name":"Jennifer M. Rutkowsky","orcid":"0000-0002-0046-7693","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:00:38.888629Z","pmid":"38613791","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}