{"doi":"10.18632/aging.205112","title":"BMAL1 modulates senescence programming via AP-1","abstract":"Cellular senescence and circadian dysregulation are biological hallmarks of aging. Whether they are coordinately regulated has not been thoroughly studied. We hypothesize that BMAL1, a pioneer transcription factor and master regulator of the molecular circadian clock, plays a role in the senescence program. Here, we demonstrate BMAL1 is significantly upregulated in senescent cells and has altered rhythmicity compared to non-senescent cells. Through BMAL1-ChIP-seq, we show that BMAL1 is uniquely localized to genomic motifs associated with AP-1 in senescent cells. Integration of BMAL1-ChIP-seq data with RNA-seq data revealed that BMAL1 presence at AP-1 motifs is associated with active transcription. Finally, we showed that BMAL1 contributes to AP-1 transcriptional control of key features of the senescence program, including altered regulation of cell survival pathways, and confers resistance to drug-induced apoptosis. Overall, these results highlight a previously unappreciated role of the core circadian clock component BMAL1 on the molecular phenotype of senescent cells.","journal":"Aging","year":2023,"id":348553,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384813,"name":"Jian Zhong","orcid":"0000-0001-7157-603X","position":1,"is_corresponding":false},{"id":70829,"name":"Tamás Ördög","orcid":"0000-0002-3940-7284","position":2,"is_corresponding":false},{"id":70826,"name":"Jeong‐Heon Lee","orcid":"0000-0003-4007-9166","position":3,"is_corresponding":false},{"id":851375,"name":"Aditya Bhagwate","orcid":"0000-0003-0192-9594","position":4,"is_corresponding":false},{"id":804341,"name":"Nagaswaroop Kengunte Nagaraj","orcid":"0000-0002-4442-2585","position":5,"is_corresponding":false},{"id":302021,"name":"Jennifer J. Westendorf","orcid":"0000-0002-4464-6108","position":6,"is_corresponding":false},{"id":233687,"name":"João F. Passos","orcid":"0000-0001-8765-1890","position":7,"is_corresponding":false},{"id":241936,"name":"Aleksey V. Matveyenko","orcid":"0000-0001-7761-4842","position":8,"is_corresponding":false},{"id":233685,"name":"Nathan K. LeBrasseur","orcid":"0000-0002-2002-0418","position":9,"is_corresponding":false},{"id":432196,"name":"Sarah K. Jachim","orcid":"0000-0002-2882-9799","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T01:12:10.335697Z","pmid":"37819791","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}