{"doi":"10.18632/aging.103116","title":"Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen","abstract":null,"journal":"Aging","year":2020,"id":643535,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1674466,"name":"Leah Truckenbrod","orcid":null,"position":1,"is_corresponding":false},{"id":1674467,"name":"Quinten Federico","orcid":null,"position":2,"is_corresponding":false},{"id":1276222,"name":"Keila Campos","orcid":null,"position":3,"is_corresponding":false},{"id":1674468,"name":"Brianna Moon","orcid":null,"position":4,"is_corresponding":false},{"id":1674469,"name":"Nedi Ferekides","orcid":null,"position":5,"is_corresponding":false},{"id":1674470,"name":"Meagan Hoppe","orcid":null,"position":6,"is_corresponding":false},{"id":1674471,"name":"Dominic D’Agostino","orcid":null,"position":7,"is_corresponding":false},{"id":672021,"name":"Sara Burke","orcid":"0000-0001-9419-1642","position":8,"is_corresponding":false},{"id":1674465,"name":"Abbi Hernandez","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen","abstract":"The ability to switch between glycolysis and ketosis promotes survival by enabling metabolism through fat oxidation during periods of fasting. Carbohydrate restriction or stress can also elicit metabolic switching. Keto-adapting from glycolysis is delayed in aged rats, but factors mediating this age-related impairment have not been identified. We measured metabolic switching between glycolysis and ketosis, as well as glycogen dynamics, in young and aged rats undergoing time-restricted feeding (TRF) with a standard diet or a low carbohydrate ketogenic diet (KD). TRF alone reversed markers of insulin-related metabolic deficits and accelerated metabolic switching in aged animals. A KD+TRF, however, provided additive benefits on these variables. Remarkably, the ability to keto-adapt was not related to glycogen levels and KD-fed rats showed an enhanced elevation in glucose following epinephrine administration. This study provides new insights into the mechanisms of keto-adaptation demonstrating the utility of dietary interventions to treat metabolic impairments across the lifespan.","is_dataset_classified":null,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32369441","pmcid":"PMC7244089","openalex_id":"https://openalex.org/W3022000657","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"RF1 AG060977","title":null},{"funder_name":"NIA NIH HHS","grant_id":"F31 AG058455","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"T32 HD071866","title":null},{"funder_name":"National Institutes of Health","grant_id":"1F31AG058455-01","title":"Metabolic Mechanisms for Treating Cognitive Aging"},{"funder_name":"National Institutes of Health","grant_id":"1RF1AG060977-01","title":"Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers Disease"}],"total_grants":5,"fwci":1.5866,"citation_percentile":0.83051328,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2020,"count":3},{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":6},{"year":2025,"count":12},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.18632/aging.103116","host_type":"journal"},{"url":"https://doi.org/10.18632/aging.103116","host_type":"publisher"},{"url":"https://www.aging-us.com/lookup/doi/10.18632/aging.103116","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32369441","host_type":"repository"},{"url":"https://digitalcommons.usf.edu/mpp_facpub/31","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7244089","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7244089","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7244089?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1101/2019.12.12.874297","host_type":""},{"url":"http://dx.doi.org/10.18632/aging.103116","host_type":""},{"url":"https://dx.doi.org/10.18632/aging.103116","host_type":""},{"url":"https://dx.doi.org/10.1101/2019.12.12.874297","host_type":""},{"url":"http://dx.doi.org/10.1101/2019.12.12.874297","host_type":""},{"url":"https://doi.org/https://doi.org/10.18632/aging.103116","host_type":""}],"fields_of_study":["Diet and metabolism studies","Dietary Effects on Health","Adipose Tissue and Metabolism","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Adaptation, Physiological","Aging","Animals","Blood Glucose","Diet, Ketogenic","Disease Models, Animal","Glycogen","Glycolysis","Ketosis","Male","Rats","Rats, Inbred BN","Rats, Inbred F344"],"mesh_terms":["Adaptation, Physiological","Aging","Animals","Blood Glucose","Disease Models, Animal","Glycogen","Glycolysis","Ketosis","Male","Rats, Inbred BN","Rats, Inbred F344","Rats","Diet, Ketogenic"],"keywords":["Ketosis","Glycogen","Ketogenic diet","Endocrinology","Glycolysis","Internal medicine","Carbohydrate","Metabolic adaptation","Carbohydrate metabolism","Insulin","Biology","Metabolism","Medicine","Diabetes mellitus","Neuroscience","Glucose","Diet","Intermittent Fasting","Keto-adaptation","Blood Glucose","Male","570","Aging","610","Rats, Inbred BN","Medicine and Health Sciences","Animals","Pharmacy and Pharmaceutical Sciences","Adaptation, Physiological","Rats, Inbred F344","Rats","Disease Models, Animal","Diet, Ketogenic","Research Paper"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T17:33:39.796618Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}