{"doi":"10.18632/aging.102738","title":"Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study","abstract":"Higher body mass index (BMI) in late-life has recently been considered as a possible protective factor for Alzheimer's disease (AD), which yet remains conflicting. To test this hypothesis, we have evaluated the cross-sectional and longitudinal associations of BMI categories with CSF biomarkers, brain β-amyloid (Aβ) load, brain structure, and cognition and have assessed the effect of late-life BMI on AD risk in a large sample (n = 1,212) of non-demented elderly from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. At baseline, higher late-life BMI categories were associated with higher levels of CSF Aβ42 (p=0.037), lower levels of CSF total-tau (t-tau, p=0.026) and CSF t-tau/Aβ42 (p=0.008), lower load of Aβ in the right hippocampus (p=0.030), as well as larger volumes of hippocampus (p<0.0001), entorhinal cortex (p=0.009) and middle temporal lobe (p=0.040). But no association was found with CSF phosphorylated-tau (p-tau) or CSF p-tau/Aβ42. Longitudinal studies showed that higher BMI individuals experienced a slower decline in cognitive function. In addition, Kaplan-Meier survival analysis revealed that higher late-life BMI had a reduced risk of progression to AD over time (p = 0.009). Higher BMI in late-life decreased the risk of AD, and this process may be driven by AD-related biomarkers.","journal":"Aging","year":2020,"id":56150,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":87,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":229339,"name":"Alzheimer’s Disease Neuroimaging Initiative","orcid":null,"position":1,"is_corresponding":false},{"id":291629,"name":"Zuo-Teng Wang","orcid":"0000-0002-7404-1759","position":2,"is_corresponding":false},{"id":293500,"name":"Fu-Rong Sun","orcid":null,"position":3,"is_corresponding":false},{"id":291630,"name":"Xue‐Ning Shen","orcid":"0009-0001-2658-3799","position":4,"is_corresponding":false},{"id":291631,"name":"Wei Xu","orcid":"0000-0002-3310-5875","position":5,"is_corresponding":false},{"id":293501,"name":"Ya‐Hui Ma","orcid":null,"position":6,"is_corresponding":false},{"id":291632,"name":"Qiang Dong","orcid":"0000-0002-3874-0130","position":7,"is_corresponding":false},{"id":291633,"name":"Lan Tan","orcid":"0000-0002-8759-7588","position":8,"is_corresponding":false},{"id":284702,"name":"Jin‐Tai Yu","orcid":"0000-0002-7686-0547","position":9,"is_corresponding":false},{"id":291628,"name":"Zhen Sun","orcid":"0000-0001-5380-6831","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T21:05:49.581291Z","pmid":"31986486","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}