{"doi":"10.18383/j.tom.2020.00001","title":"The Longitudinal Imaging Tracker (BrICS-LIT):A Cloud Platform for Monitoring Treatment Response in Glioblastoma Patients","abstract":"Glioblastoma is a common and aggressive form of brain cancer affecting up to 20,000 new patients in the US annually. Despite rigorous therapies, current median survival is only 15-20 months. Patients who complete initial treatment undergo follow-up imaging at routine intervals to assess for tumor recurrence. Imaging is a central part of brain tumor management, but MRI findings in patients with brain tumor can be challenging to interpret and are further confounded by interpretation variability. Disease-specific structured reporting attempts to reduce variability in imaging results by implementing well-defined imaging criteria and standardized language. The Brain Tumor Reporting and Data System (BT-RADS) is one such framework streamlined for clinical workflows and includes quantitative criteria for more objective evaluation of follow-up imaging. To facilitate accurate and objective monitoring of patients during the follow-up period, we developed a cloud platform, the Brain Imaging Collaborative Suite's Longitudinal Imaging Tracker (BrICS-LIT). BrICS-LIT uses semiautomated tumor segmentation algorithms of both T2-weighted FLAIR and contrast-enhanced T1-weighted MRI to assist clinicians in quantitative assessment of brain tumors. The LIT platform can ultimately guide clinical decision-making for patients with glioblastoma by providing quantitative metrics for BT-RADS scoring. Further, this platform has the potential to increase objectivity when measuring efficacy of novel therapies for patients with brain tumor during their follow-up. Therefore, LIT will be used to track patients in a dose-escalated clinical trial, where spectroscopic MRI has been used to guide radiation therapy (Clinicaltrials.gov NCT03137888), and compare patients to a control group that received standard of care.","journal":"Tomography","year":2020,"id":86912,"datarank":0.5554422753797228,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.17069987176049217,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.17069987176049217,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03137888"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428904,"name":"Saumya Gurbani","orcid":"0000-0003-3524-3726","position":1,"is_corresponding":false},{"id":318014,"name":"Eric A. Mellon","orcid":"0000-0001-9892-8402","position":2,"is_corresponding":false},{"id":442400,"name":"Vicki Huang","orcid":"0000-0003-3029-4700","position":3,"is_corresponding":false},{"id":388235,"name":"Mohammed Goryawala","orcid":"0000-0002-6875-2191","position":4,"is_corresponding":false},{"id":256332,"name":"Peter B. Barker","orcid":"0000-0002-6410-7793","position":5,"is_corresponding":false},{"id":250706,"name":"Lawrence Kleinberg","orcid":"0000-0003-2473-2305","position":6,"is_corresponding":false},{"id":294153,"name":"Hui‐Kuo G. Shu","orcid":"0000-0002-4060-0874","position":7,"is_corresponding":false},{"id":375815,"name":"Hyunsuk Shim","orcid":"0000-0001-8313-2612","position":8,"is_corresponding":false},{"id":428905,"name":"Brent D. Weinberg","orcid":"0000-0002-7992-1747","position":9,"is_corresponding":false},{"id":442399,"name":"Karthik Ramesh","orcid":"0000-0001-9052-8973","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32548285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}