{"doi":"10.18240/ijo.2025.08.11","title":"Systemic C-reactive protein levels in patients with geographic atrophy stratified by sex","abstract":"AIM: To determine the differences in levels of systemic C-reactive protein (CRP) in patients with geographic atrophy (GA) and sex-based differences in CRP levels. METHODS: Blood samples from patients with GA and controls were collected in a prospective age-related macular degeneration (AMD) registry from August 2014 to June 2021. AMD was confirmed using multimodal imaging and the Beckman and Consensus of Atrophy Meeting criteria for GA. High-sensitivity serum CRP levels were measured using an automated nephelometer. A non-parametric (rank-based) linear regression model was fit with an interaction between sex and GA. RESULTS: There were 97 GA patients and 139 controls, with females comprising 55% and 66% of each cohort, respectively. There is no difference in CRP between cases and controls, with a median (interquartile range) of 1.2 (0.6-2.6) mg/L in GA patients versus 1.3 (0.8–2.9) mg/L in controls (P=0.52). Although females had higher CRP levels compared to males in both the GA and control groups, this difference did not reach statistical significance after adjustment for multiple comparisons. CONCLUSION: There is no significant difference in systemic CRP levels between GA cases and controls.","journal":"International Journal of Ophthalmology","year":2025,"id":572029,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6222,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":351431,"name":"Brandie D. Wagner","orcid":"0000-0002-2745-0103","position":1,"is_corresponding":false},{"id":714165,"name":"Jennifer L. Patnaik","orcid":"0000-0002-0375-0187","position":2,"is_corresponding":false},{"id":1478291,"name":"Talisa E. de Carlo Forest","orcid":null,"position":3,"is_corresponding":false},{"id":750519,"name":"Marc T. Mathias","orcid":null,"position":4,"is_corresponding":false},{"id":913430,"name":"Niranjan Manoharan","orcid":"0000-0001-5746-6854","position":5,"is_corresponding":false},{"id":1112810,"name":"Vivian Rajeswaren","orcid":"0000-0001-7654-0984","position":6,"is_corresponding":false},{"id":749862,"name":"Naresh Mandava","orcid":"0000-0003-3251-6469","position":7,"is_corresponding":false},{"id":311040,"name":"Anne M. Lynch","orcid":"0000-0001-6508-8136","position":8,"is_corresponding":false},{"id":1112812,"name":"Ramya Gnanaraj","orcid":"0000-0002-8559-7963","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:57:19.669553Z","pmid":"40827292","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}