{"doi":"10.18174/589777","title":"Nutritional factors to support bone health in older adults","abstract":"Protein may play a beneficial role in the prevention of bone loss and in slowing down osteoporosis.The effect of dietary protein may be different in older adults compared to younger adults, since this population has a greater need for protein.The aim of this systematic review and meta-analysis was to investigate the impact of a dietary protein intake above the Recommended Dietary Allowance (RDA) of 0.8 g/kg body weight/day from any source on Bone Mineral Density (BMD)/Bone Mineral Content (BMC), bone turnover markers, and fracture risk in older adults compared to a lower dietary protein intake.A systematic search was conducted through October 2018 in 3 databases: CENTRAL, MEDLINE, and EMBASE.We included all prospective cohort studies and Randomized Controlled Trials (RCTs) among adults aged ≥65 years that examined the relation between protein intake on bone health outcomes.Two investigators independently conducted abstract and fulltext screenings, data extractions, and risk of bias assessments.Authors were contacted for missing data.After screening of 523 records, twelve cohort studies and one RCT were included.Qualitative evaluation showed a positive trend between higher protein intakes and higher femoral neck and total hip BMD.Meta-analysis of four cohort studies showed that higher protein intakes resulted in a significant decrease in hip fractures (pooled hazard ratio: 0.89; 95% confidence interval: 0.84, 0.94).This systematic review supports that a protein intake above the current RDA may reduce hip fracture risk and may play a beneficial role in BMD maintenance and loss in older adults.Protein and bone health: a systematic review and meta-analysis 2.1Protein and bone health: a systematic review and meta-analysis 2.1Table 2. Continued Isanejad, 2017 [29] Osteoporosis Risk Factor and Fracture Prevention Study (Finland) Women ≥65 y 750/544 68.1(1.9),65-72 3 d food records 0.79, 0.90, 0.96, 1.18 (quartiles) 3 TB BMC Per unit increase in energy-adjusted protein intake: B -0.16 SE 30.04 p 0.159 TB BMD B 0.04 SE 0.01 p 0.507 FN BMD B -0.01 SE 0.01 p 0.918 LS BMD B -0.31 SE 0.01 p 0.001 Langsetmo, 2017 [30] Osteoporotic Fractures in Men Study (US) Men ≥65 y 5994/5875 73.6(5.9)Modified Block FFQ 0.67, 0.75, 0.83, 0.93 (quartiles) 10.5-11.2Hip BMD Per SD increase in protein intake (2.9% of EI): B 0.06 SE 0.01 p <0.001 Protein and BMD: cross-sectional relationship and longitudinal effects 2.2","journal":"Socio-Environmental Systems Modeling","year":2023,"id":399949,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1176275,"name":"Inge Groenendijk","orcid":"0000-0002-4894-4380","position":0,"is_corresponding":true}],"reference_count":306,"raw_metadata":null,"created_at":"2026-07-19T01:20:00.023537Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}