{"doi":"10.17615/zts6-p216","title":"Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy","abstract":"Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug delivery systems (nano-DDS) with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, we report a novel redox dual-responsive prodrug-nanosystem self-assembled by hydrophobic small-molecule conjugates of paclitaxel (PTX) and oleic acid (OA). Thioether linked conjugates (PTX-S-OA) and dithioether inserted conjugates (PTX-2S-OA) are designed to respond to the redox-heterogeneity in tumor. Dithioether has been reported to show redox dual-responsiveness, but we find that PTX-S-OA exhibits superior redox sensitivity over PTX-2S-OA, achieving more rapid and selective release of free PTX from the prodrug nanoassemblies triggered by redox stimuli. PEGylated PTX-S-OA nanoassemblies, with impressively high drug loading (57.4%), exhibit potent antitumor activity in a human epidermoid carcinoma xenograft. This novel prodrug-nanosystem addresses concerns related to the low drug loading and ineff...","journal":"Figshare","year":2020,"id":89653,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254423,"name":"Leaf Huang","orcid":"0000-0002-9421-8283","position":1,"is_corresponding":false},{"id":331430,"name":"Lin Li","orcid":"0000-0003-0426-6546","position":2,"is_corresponding":false},{"id":311110,"name":"Dan Liu","orcid":"0000-0002-2198-3910","position":3,"is_corresponding":false},{"id":103599,"name":"Jing Li","orcid":"0000-0001-7792-4322","position":4,"is_corresponding":false},{"id":453048,"name":"Cong Luo","orcid":"0009-0000-5546-2470","position":5,"is_corresponding":false},{"id":453049,"name":"Lei Miao","orcid":"0000-0002-2281-2689","position":6,"is_corresponding":false},{"id":453050,"name":"Bingjun Sun","orcid":"0000-0001-7986-5434","position":7,"is_corresponding":false},{"id":454007,"name":"Yuqian Du","orcid":null,"position":8,"is_corresponding":false},{"id":454008,"name":"Sun, Jin","orcid":null,"position":9,"is_corresponding":false},{"id":453051,"name":"Sara Musetti","orcid":"0000-0002-5682-1225","position":10,"is_corresponding":false},{"id":453052,"name":"Xiaopeng Han","orcid":"0000-0002-7557-7133","position":11,"is_corresponding":false},{"id":453047,"name":"Zhonggui He","orcid":"0000-0002-5907-3875","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T22:02:27.195966Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}