{"doi":"10.17615/zg2v-vw38","title":"Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision","abstract":"African Americans experience an increased burden of motor vehicle collision (MVC), post-MVC musculoskeletal pain, and vitamin D insufficiency. In this prospective multicenter study, we tested the hypothesis that African Americans (n = 133) presenting to the emergency department after MVC with low peritraumatic vitamin D levels would have worse chronic musculoskeletal pain outcomes compared to individuals with sufficient vitamin D. Vitamin D levels were assessed in the early aftermath of MVC through enzyme-linked immunosorbent assay, and pain severity was assessed using the 0 to 10 numeric rating scale at 6 weeks, 6 months, and 1 year. In repeated-measures analysis, African American MVC survivors with vitamin D insufficiency experienced more severe chronic pain (β = 1.18, P = 0.031). In secondary analyses, we assessed for evidence that the effect of vitamin D on post-MVC pain outcomes is mediated, at least in part, by the influence of vitamin D on genetic variants in genes involved in immune system regulation (IL-10 and NLRP3). Genotyping was performed using a genome-wide microarray using collected DNA samples. Secondary analyses suggest that the effect of vitamin D on post-MVC pain outcomes may be influenced by genetic variation in IL-10 and NLRP3. Further studies are needed to assess the impact of vitamin D insufficiency on pain outcomes in African Americans experiencing MVC and other common trauma exposures, to assess factors affecting this relationship, and to assess the efficacy of administering vitamin D in the immediate aftermath of MVC to prevent chronic pain. Such low-cost, nonopioid interventions are urgently needed to address chronic pain development after MVC.","journal":"UNC Libraries","year":2021,"id":229920,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":834988,"name":"J.P. Ting","orcid":null,"position":1,"is_corresponding":false},{"id":835389,"name":"A. Bortsov","orcid":null,"position":2,"is_corresponding":false},{"id":835390,"name":"S.D. Linnstaedt","orcid":null,"position":3,"is_corresponding":false},{"id":835391,"name":"S.A. McLean","orcid":null,"position":4,"is_corresponding":false},{"id":835392,"name":"P.L. Hendry","orcid":null,"position":5,"is_corresponding":false},{"id":835393,"name":"M.-A. Velilla","orcid":null,"position":6,"is_corresponding":false},{"id":835394,"name":"M.C. Mauck","orcid":null,"position":7,"is_corresponding":false},{"id":835395,"name":"R. Domeier","orcid":null,"position":8,"is_corresponding":false},{"id":835396,"name":"M. Kurz","orcid":null,"position":9,"is_corresponding":false},{"id":835397,"name":"Colorado Pearson","orcid":null,"position":10,"is_corresponding":false},{"id":835398,"name":"C. Lewandowski","orcid":null,"position":11,"is_corresponding":false},{"id":835399,"name":"E. Datner","orcid":null,"position":12,"is_corresponding":false},{"id":596465,"name":"R.B. Fillingim","orcid":null,"position":13,"is_corresponding":false},{"id":835388,"name":"F.L. Beaudoin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:01.675482Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}