{"doi":"10.17615/zbbj-am42","title":"The Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos.","abstract":"BACKGROUND: Visual impairment could worsen sleep/wake disorders and cognitive decline. OBJECTIVE: To examine interrelations among self-reported visual impairment, sleep, and cognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Miami-site. METHOD: HCHS/SOL Miami-site participants ages 45-74 years (n = 665) at Visit-1, who returned for cognitive test 7-years later (SOL-INCA). Participants completed the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ), validated sleep questionnaires and test for obstructive sleep apnea (OSA) at Visit-1. We obtained verbal episodic learning and memory, verbal fluency, processing speed, and executive functioning at Visit-1 and at SOL-INCA. Processing speed/executive functioning were added to SOL-INCA. We examined global cognition and change using a regression-based reliable change index, adjusting for the time lapse between Visit-1 and SOL-INCA. We used regression models to test whether 1) persons with OSA, self-reported sleep duration, insomnia, and sleepiness have an increased risk for visual impairment, 2a) visual impairment is associated with worse cognitive function and/or decline, and 2b) sleep disorders attenuate these associations. RESULT: Sleepiness (β= 0.04; p < 0.01) and insomnia (β= 0.04; p < 0.001) were cross-sectionally associated with visual impairment, adjusting for sociodemographic characteristics, behavioral factors, acculturation, and health conditions. Visual impairment was associated with lower global cognitive function at Visit-1 (β= -0.16; p < 0.001) and on average 7-years later (β= -0.18; p < 0.001). Visual impairment was also associated with a change in verbal fluency (β= -0.17; p < 0.01). OSA, self-reported sleep duration, insomnia, and sleepiness did not attenuate any of the associations. CONCLUSION: Self-reported visual impairment was independently associated with worse cognitive function and decline.","journal":"UNC Libraries","year":2025,"id":577714,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":837113,"name":"D. Diane Zheng","orcid":"0000-0003-2913-2878","position":1,"is_corresponding":false},{"id":303809,"name":"Ariana M. Stickel","orcid":"0000-0002-6312-2377","position":2,"is_corresponding":false},{"id":247841,"name":"Delia Cabrera DeBuc","orcid":"0000-0002-4726-894X","position":3,"is_corresponding":false},{"id":709798,"name":"Elizabeth Mahanna","orcid":"0000-0002-1297-1432","position":4,"is_corresponding":false},{"id":303812,"name":"Hector M. González","orcid":"0000-0003-4867-7902","position":5,"is_corresponding":false},{"id":303806,"name":"Wassim Tarraf","orcid":"0000-0001-8888-7918","position":6,"is_corresponding":false},{"id":790614,"name":"Martha L Daviglus","orcid":null,"position":7,"is_corresponding":false},{"id":430632,"name":"Carlos E. Mendoza‐Santiesteban","orcid":"0000-0002-6344-4544","position":8,"is_corresponding":false},{"id":1082243,"name":"Sayaka Kuwayama","orcid":null,"position":9,"is_corresponding":false},{"id":336205,"name":"David Lee","orcid":"0000-0002-7536-9692","position":10,"is_corresponding":false},{"id":737565,"name":"Sonya Kaur","orcid":"0000-0003-4962-6066","position":11,"is_corresponding":false},{"id":514843,"name":"Charlotte E. Joslin","orcid":"0000-0002-1402-3989","position":12,"is_corresponding":false},{"id":298685,"name":"Alberto R. Ramos","orcid":"0000-0002-9861-6609","position":13,"is_corresponding":false},{"id":577698,"name":"Jianwen Cai","orcid":"0000-0003-1813-0594","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:16.148027Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}