{"doi":"10.17615/yyyb-0w74","title":"Sleep Apnea Symptoms and Risk of Temporomandibular Disorder: OPPERA Cohort","abstract":"The authors tested the hypothesis that obstructive sleep apnea (OSA) signs/symptoms are associated with the occurrence of temporomandibular disorder (TMD), using the OPPERA prospective cohort study of adults aged 18 to 44 years at enrollment (n = 2,604) and the OPPERA case-control study of chronic TMD (n = 1,716). In both the OPPERA cohort and case-control studies, TMD was examiner determined according to established research diagnostic criteria. People were considered to have high likelihood of OSA if they reported a history of sleep apnea or ≥ 2 hallmarks of OSA: loud snoring, daytime sleepiness, witnessed apnea, and hypertension. Cox proportional hazards regression estimated hazard ratios (HRs) and 95% confidence limits (CL) for first-onset TMD. Logistic regression estimated odds ratios (OR) and 95% CL for chronic TMD. In the cohort, 248 individuals developed first-onset TMD during the median 2.8-year follow-up. High likelihood of OSA was associated with greater incidence of first-onset TMD (adjusted HR = 1.73; 95% CL, 1.14, 2.62). In the case-control study, high likelihood of OSA was associated with higher odds of chronic TMD (adjusted OR = 3.63; 95% CL, 2.03, 6.52). Both studies supported a significant association of OSA symptoms and TMD, with prospective cohort evidence finding that OSA symptoms preceded first-onset TMD.","journal":"UNC Libraries","year":2020,"id":67224,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":357471,"name":"R. Fillingim","orcid":null,"position":1,"is_corresponding":false},{"id":357472,"name":"L. Diatchenko","orcid":null,"position":2,"is_corresponding":false},{"id":357473,"name":"R. Dubner","orcid":null,"position":3,"is_corresponding":false},{"id":301597,"name":"Gary D. Slade","orcid":"0000-0002-4065-6341","position":4,"is_corresponding":false},{"id":357474,"name":"G.K. Essick","orcid":null,"position":5,"is_corresponding":false},{"id":357475,"name":"W. Maixner","orcid":null,"position":6,"is_corresponding":false},{"id":357476,"name":"J.D. Greenspan","orcid":null,"position":7,"is_corresponding":false},{"id":357477,"name":"A.E. Sanders","orcid":null,"position":8,"is_corresponding":false},{"id":357478,"name":"V.E. Miller","orcid":null,"position":9,"is_corresponding":false},{"id":357479,"name":"E. Bair","orcid":null,"position":10,"is_corresponding":false},{"id":357480,"name":"C. Knott","orcid":null,"position":11,"is_corresponding":false},{"id":357470,"name":"R. Ohrbach","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T21:15:12.020735Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}