{"doi":"10.17615/yjnv-8m57","title":"Oligoclonal CD8+ T Cells Play a Critical Role in the Development of Hypertension","abstract":"Recent studies have emphasized a role of adaptive immunity, and particularly T cells, in the genesis of hypertension. We sought to determine the T-cell subtypes that contribute to hypertension and renal inflammation in angiotensin II-induced hypertension. Using T-cell receptor spectratyping to examine T-cell receptor usage, we demonstrated that CD8(+) cells, but not CD4(+) cells, in the kidney exhibited altered T-cell receptor transcript lengths in Vβ3, 8.1, and 17 families in response to angiotensin II-induced hypertension. Clonality was not observed in other organs. The hypertension caused by angiotensin II in CD4(-/-) and MHCII(-/-) mice was similar to that observed in wild-type mice, whereas CD8(-/-) mice and OT1xRAG-1(-/-) mice, which have only 1 T-cell receptor, exhibited a blunted hypertensive response to angiotensin II. Adoptive transfer of pan T cells and CD8(+) T cells but not CD4(+)/CD25(-) cells conferred hypertension to RAG-1(-/-) mice. In contrast, transfer of CD4(+)/CD25(+) cells to wild-type mice receiving angiotensin II decreased blood pressure. Mice treated with angiotensin II exhibited increased numbers of kidney CD4(+) and CD8(+) T cells. In response to a sodium/volume challenge, wild-type and CD4(-/-) mice infused with angiotensin II retained water and sodium, whereas CD8(-/-) mice did not. CD8(-/-) mice were also protected against angiotensin-induced endothelial dysfunction and vascular remodeling in the kidney. These data suggest that in the development of hypertension, an oligoclonal population of CD8(+) cells accumulates in the kidney and likely contributes to hypertension by contributing to sodium and volume retention and vascular rarefaction.","journal":"UNC Libraries","year":2020,"id":76604,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105129,"name":"Yu Shyr","orcid":"0000-0003-2086-9670","position":1,"is_corresponding":false},{"id":399576,"name":"Jing Wu","orcid":"0000-0003-2013-2863","position":2,"is_corresponding":false},{"id":16600,"name":"David G. Harrison","orcid":null,"position":3,"is_corresponding":false},{"id":399577,"name":"Hana A. Itani","orcid":"0000-0001-9921-5885","position":4,"is_corresponding":false},{"id":400896,"name":"Daniel W. Trott","orcid":null,"position":5,"is_corresponding":false},{"id":400897,"name":"Salim Thabet","orcid":null,"position":6,"is_corresponding":false},{"id":290002,"name":"Allison E. Norlander","orcid":"0000-0002-9357-485X","position":7,"is_corresponding":false},{"id":298182,"name":"Wei Chen","orcid":"0000-0002-3973-340X","position":8,"is_corresponding":false},{"id":327653,"name":"Anna E. Goldstein","orcid":null,"position":9,"is_corresponding":false},{"id":399578,"name":"Mohamed A. Saleh","orcid":"0000-0002-6405-6033","position":10,"is_corresponding":false},{"id":400898,"name":"Chung-I. Li","orcid":null,"position":11,"is_corresponding":false},{"id":265986,"name":"Annet Kirabo","orcid":"0000-0001-8580-9359","position":12,"is_corresponding":false},{"id":16598,"name":"Meena S. Madhur","orcid":"0000-0002-0407-634X","position":13,"is_corresponding":false},{"id":400895,"name":"William J. Arendshorst","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T21:48:27.511277Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}