{"doi":"10.17615/y01f-5332","title":"A cord blood monocyte–derived cell therapy product accelerates brain remyelination","abstract":"Microglia and monocytes play important roles in regulating brain remyelination. We developed DUOC-01, a cell therapy product intended for treatment of demyelinating diseases, from banked human umbilical cord blood (CB) mononuclear cells. Immunodepletion and selection studies demonstrated that DUOC-01 cells are derived from CB CD14+ monocytes. We compared the ability of freshly isolated CB CD14+ monocytes and DUOC-01 cells to accelerate remyelination of the brains of NOD/SCID/IL2Rγ null mice following cuprizone feeding-mediated demyelination. The corpus callosum of mice intracranially injected with DUOC-01 showed enhanced myelination, a higher proportion of fully myelinated axons, decreased gliosis and cellular infiltration, and more proliferating oligodendrocyte lineage cells than those of mice receiving excipient. Uncultured CB CD14+ monocytes also accelerated remyelination, but to a significantly lesser extent than DUOC-01 cells. Microarray analysis, quantitative PCR studies, Western blotting, and flow cytometry demonstrated that expression of factors that promote remyelination including PDGF-AA, stem cell factor, IGF1, MMP9, MMP12, and triggering receptor expressed on myeloid cells 2 were upregulated in DUOC-01 compared to CB CD14+ monocytes. Collectively, our results show that DUOC-01 accelerates brain remyelination by multiple mechanisms and could be beneficial in treating demyelinating conditions.","journal":"UNC Libraries","year":2024,"id":501229,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366102,"name":"Arjun Saha","orcid":"0000-0001-5080-307X","position":1,"is_corresponding":false},{"id":581664,"name":"Jesse D. Troy","orcid":"0000-0001-5410-8146","position":2,"is_corresponding":false},{"id":1350764,"name":"Susan Buntz","orcid":null,"position":3,"is_corresponding":false},{"id":1350765,"name":"Amy Wollish","orcid":null,"position":4,"is_corresponding":false},{"id":1350766,"name":"Sachit Patel","orcid":null,"position":5,"is_corresponding":false},{"id":298497,"name":"Joanne Kurtzberg","orcid":"0000-0002-3370-0703","position":6,"is_corresponding":false},{"id":219937,"name":"Glenn K. Matsushima","orcid":null,"position":7,"is_corresponding":false},{"id":1350486,"name":"Li Xu","orcid":"0000-0002-1676-3841","position":8,"is_corresponding":false},{"id":1350767,"name":"Paula Scotland","orcid":null,"position":9,"is_corresponding":false},{"id":1350487,"name":"Aruni Gunaratne","orcid":"0000-0003-4977-3605","position":10,"is_corresponding":false},{"id":1350768,"name":"Andrew E. Balber","orcid":null,"position":11,"is_corresponding":false},{"id":1350769,"name":"Pamela Noeldner","orcid":null,"position":12,"is_corresponding":false},{"id":1350763,"name":"Tracy Gentry","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:12.068207Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}