{"doi":"10.17615/xzt5-ab91","title":"Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals","abstract":"Approximately 75% of the global human population are lactose malabsorbers. In a previous clinical trial, it was shown that feeding a high-purity galactooligosaccharide (>95% GOS) could improve symptoms of lactose-intolerant subjects, attaining lactose tolerance in a majority of subjects. To investigate the mechanism, we examined the microbiome of human subjects before and after GOS feeding. The results show a significant shift in the microbiome of responsive individuals, including lactose-fermenting microbes in their stools. The high-purity prebiotic GOS resulted in adaptive shifts in the microbiome and correlated with improvement in clinical symptoms.","journal":"UNC Libraries","year":2020,"id":85961,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":440557,"name":"Todd R. Klaenhammer","orcid":null,"position":1,"is_corresponding":false},{"id":60558,"name":"Scott T. Magness","orcid":"0000-0002-2746-1224","position":2,"is_corresponding":false},{"id":439236,"name":"Dennis A. Savaiano","orcid":"0000-0001-8872-6276","position":3,"is_corresponding":false},{"id":440558,"name":"Andrew J. Ritter","orcid":null,"position":4,"is_corresponding":false},{"id":440559,"name":"Carlton P. Anderson","orcid":null,"position":5,"is_corresponding":false},{"id":439237,"name":"Andrea Monteagudo-Mera","orcid":"0000-0003-3777-0191","position":6,"is_corresponding":false},{"id":245450,"name":"M. Andrea Azcárate-Peril","orcid":"0000-0003-0325-1289","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T21:58:41.997408Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}