{"doi":"10.17615/xwve-c619","title":"Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus","abstract":"Apoptotic debris, autoantibody, and IgG-immune complexes (ICs) have long been implicated in the inflammation associated with systemic lupus erythematosus (SLE); however, it remains unclear whether they initiate immune-mediated events that promote disease. In this study, we show that peripheral blood mononuclear cells from SLE patients experiencing active disease, and hematopoietic cells from lupus-prone MRL/lpr and NZM2410 mice accumulate markedly elevated levels of surface-bound nuclear self-antigens. On dendritic cells (DCs) and macrophages (MFs), the self-antigens are part of IgG-ICs that promote FcγRI-mediated signal transduction. Accumulation of IgG-ICs is evident on ex vivo myeloid cells from MRL/lpr mice by 10 weeks of age, and steadily increases prior to lupus nephritis. IgG and FcγRI play a critical role in disease pathology. Passive transfer of pathogenic IgG into IgG-deficient MRL/lpr mice promotes the accumulation of IgG-ICs prior to significant B cell expansion, BAFF secretion, and lupus nephritis. In contrast, diminishing the burden IgG-ICs in MRL/lpr mice through deficiency in FcγRI markedly improves these lupus pathologies. Together, our findings reveal a previously unappreciated role for the cell surface accumulation of IgG-ICs in human and murine lupus.","journal":"UNC Libraries","year":2020,"id":117225,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281459,"name":"Yuri Fedoriw","orcid":"0000-0002-2135-2908","position":1,"is_corresponding":false},{"id":513037,"name":"Young K. Truong","orcid":"0009-0003-8679-2917","position":2,"is_corresponding":false},{"id":275084,"name":"Barbara J. Vilen","orcid":"0000-0003-0014-0022","position":3,"is_corresponding":false},{"id":546747,"name":"Marilyn Diaz","orcid":"0000-0002-3046-2746","position":4,"is_corresponding":false},{"id":373590,"name":"Jennifer L. Rogers","orcid":"0000-0003-1755-7684","position":5,"is_corresponding":false},{"id":541448,"name":"Stephen H. Clarke","orcid":null,"position":6,"is_corresponding":false},{"id":547427,"name":"Sunah Kang","orcid":null,"position":7,"is_corresponding":false},{"id":547428,"name":"Chuancang Jiang","orcid":null,"position":8,"is_corresponding":false},{"id":546748,"name":"Andrew J. Monteith","orcid":"0000-0002-7259-6574","position":9,"is_corresponding":false},{"id":546749,"name":"Teresa K. Tarrant","orcid":"0000-0003-4067-5363","position":10,"is_corresponding":false},{"id":492235,"name":"John L. Schmitz","orcid":"0000-0002-1425-236X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:51.309289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}