{"doi":"10.17615/xg4b-j958","title":"Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance","abstract":"Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR 6.13, 95%CI 1.15–48.65, p=0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.","journal":"UNC Libraries","year":2020,"id":143671,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":612177,"name":"M. Cline","orcid":null,"position":1,"is_corresponding":false},{"id":534079,"name":"R. A. Salata","orcid":null,"position":2,"is_corresponding":false},{"id":534080,"name":"K. S. Kaye","orcid":null,"position":3,"is_corresponding":false},{"id":534075,"name":"S. S. Richter","orcid":null,"position":4,"is_corresponding":false},{"id":534076,"name":"R. A. Bonomo","orcid":null,"position":5,"is_corresponding":false},{"id":281109,"name":"Robert C. Kalayjian","orcid":"0000-0001-7114-726X","position":6,"is_corresponding":false},{"id":612178,"name":"S. R. Evans","orcid":null,"position":7,"is_corresponding":false},{"id":534081,"name":"V. G. Fowler","orcid":null,"position":8,"is_corresponding":false},{"id":232741,"name":"David van Duin","orcid":"0000-0003-4784-3227","position":9,"is_corresponding":false},{"id":534078,"name":"F. Perez","orcid":null,"position":10,"is_corresponding":false},{"id":612176,"name":"E. D. Cober","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:17:41.821196Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}