{"doi":"10.17615/wxk8-tb49","title":"Long-term remission in multiply relapsed enteropathy-associated T-cell lymphoma following CD30 CAR T-cell therapy","abstract":"Enteropathy-associated T-cell lymphoma (EATL) is a rare lymphoma arising in the setting of celiac disease. Multiagent anthracycline-based chemotherapy alone is associated with poor long-term outcomes with a median overall survival of only 7 months. In patients who achieve a response to firstline therapy and are eligible for autologous stem cell transplantation (SCT), 5-year median overall survival can be improved to 50% to 60%. Because ~50% of patients with EATL express the CD30 antigen, targeted therapy with brentuximab vedotin has been explored with promising outcomes. We have recently completed a phase 1/2 study showing safety and efficacy of chimeric antigen receptor (CAR)–modified T cells targeting the CD30 molecule (CD30 CAR T cells) in CD301 Hodgkin lymphoma. Here we describe a patient with multiply relapsed EATL after previous allogeneic SCT (allo-SCT) who achieved a durable remission with CD30 CAR T cells.","journal":"UNC Libraries","year":2021,"id":229890,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":835171,"name":"N. Ghosh","orcid":null,"position":1,"is_corresponding":false},{"id":267719,"name":"Jason P. Block","orcid":"0000-0001-7660-9064","position":2,"is_corresponding":false},{"id":43584,"name":"C. Cheng","orcid":null,"position":3,"is_corresponding":false},{"id":835172,"name":"J. Serody","orcid":null,"position":4,"is_corresponding":false},{"id":771149,"name":"B. Savoldo","orcid":null,"position":5,"is_corresponding":false},{"id":744177,"name":"G. Dotti","orcid":null,"position":6,"is_corresponding":false},{"id":835173,"name":"A.W. Beaven","orcid":null,"position":7,"is_corresponding":false},{"id":835174,"name":"N. Grover","orcid":null,"position":8,"is_corresponding":false},{"id":835175,"name":"K. Morrison","orcid":null,"position":9,"is_corresponding":false},{"id":396585,"name":"A. Ivanova","orcid":null,"position":10,"is_corresponding":false},{"id":835170,"name":"T.J. Voorhees","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:01.675482Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}