{"doi":"10.17615/wwxe-yn94","title":"Male circumcision reduces penile hpv incidence and persistence: A randomized controlled trial in Kenya","abstract":"Background: Male circumcision reduces the risk of human immunodeficiency virus infection in men. We assessed the effect of male circumcision on the incidence and natural history of human papillomavirus (HPV) in a randomized clinical trial in Kisumu, Kenya. Methods: Sexually active, 18- to 24-year-old men provided penile exfoliated cells for HPV DNA testing every 6 months for 2 years. HPV DNA was detected via GP5þ/6þ PCR in glans/coronal sulcus and in shaft samples. HPV incidence and persistence were assessed by intent-to-treat analyses. Results: A total of 2,193 men participated (1,096 randomized to circumcision; 1,097 controls). HPV prevalence was 50% at baseline for both groups and dropped to 23.7% at 24 months in the circumcision group, and 41.0% in control group. Incident infection of any HPV type over 24 months was lower among men in the circumcision group than in the control group [HR ¼ 0.61; 95% confidence interval (CI), 0.52-0.72]. Clearance rate of any HPV infection over 24 months was higher in the circumcision group than in the control group (HR ¼ 1.87; 95% CI, 1.49-2.34). Lower HPV point-prevalence, lower HPV incidence, and higher HPV clearance in the circumcision group were observed in glans but not in shaft samples. Conclusion: Male circumcision reduced the risk of HPV acquisition and reinfection, and increased HPV clearance in the glans. Impact: Providing voluntary, safe, and affordable male circumcision should help reduce HPV infections in men, and consequently, HPV-associated disease in their partners.","journal":"UNC Libraries","year":2024,"id":499092,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":605465,"name":"Hrishikesh Chakraborty","orcid":"0000-0001-9078-845X","position":1,"is_corresponding":false},{"id":546406,"name":"Stephen Moses","orcid":null,"position":2,"is_corresponding":false},{"id":528926,"name":"Jennifer S. Smith","orcid":"0000-0003-1457-7735","position":3,"is_corresponding":false},{"id":130929,"name":"Michael G. Hudgens","orcid":"0000-0002-9106-4194","position":4,"is_corresponding":false},{"id":1346931,"name":"Wendy Mei","orcid":null,"position":5,"is_corresponding":false},{"id":304635,"name":"Robert C. Bailey","orcid":"0000-0002-9202-1794","position":6,"is_corresponding":false},{"id":546403,"name":"Danielle M. Backes","orcid":null,"position":7,"is_corresponding":false},{"id":61783,"name":"Chris J.L.M. Meijer","orcid":"0000-0002-2758-9463","position":8,"is_corresponding":false},{"id":1346146,"name":"Eric Röhner","orcid":"0000-0001-8329-294X","position":9,"is_corresponding":false},{"id":438003,"name":"Kawango Agot","orcid":"0000-0002-6153-8950","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}