{"doi":"10.17615/wp1b-q881","title":"Dominant-Negative Loss of PPAR  Function Enhances Smooth Muscle Cell Proliferation, Migration, and Vascular Remodeling","abstract":"The Peroxisome Proliferator Activated Receptor-gamma (PPARγ) protein is a nuclear transcriptional activator with importance in diabetes management as the molecular target for the thiazolidinedione (TZD) family of drugs. Substantial evidence indicates that the TZD family of PPARγ agonists may retard the development of atherosclerosis. However, recent clinical data has suggested that at least one TZD may increase the risk of myocardial infarction and death from cardiovascular disease. In this study, we used a genetic approach to disrupt PPARγ signaling to probe the protein's role in smooth muscle cell (SMC) responses that are important for atherosclerosis.","journal":"UNC Libraries","year":2020,"id":137613,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":598268,"name":"M. Panchatcharam","orcid":null,"position":1,"is_corresponding":false},{"id":598269,"name":"S. Miriyala","orcid":null,"position":2,"is_corresponding":false},{"id":598270,"name":"S. S. Smyth","orcid":null,"position":3,"is_corresponding":false},{"id":547575,"name":"Y.-S. Tsai","orcid":null,"position":4,"is_corresponding":false},{"id":598271,"name":"D. Meredith","orcid":null,"position":5,"is_corresponding":false},{"id":171201,"name":"N. Maeda","orcid":null,"position":6,"is_corresponding":false},{"id":598272,"name":"A. J. Morris","orcid":null,"position":7,"is_corresponding":false},{"id":442789,"name":"G. A. Stouffer","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:56.001887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}