{"doi":"10.17615/wkpv-na27","title":"A CD24-p53 axis contributes to African American prostate cancer disparities","abstract":"Background: Using a functional analysis of prostate cancer cells, we found a CD24-dependent inactivation of mutant p53, but the clinical significance of this observation remained uncertain. Here, we validated these results with samples of human prostate cancer and explored the role of a CD24-p53 axis in racial disparities of prostate cancer. Methods: Samples of formalin-fixed, paraffin-embedded prostate cancer from 141 European Americans (EAs) and 147 African Americans (AAs) in two independent sample cohorts were assessed for protein expression of CD24, mutant p53, mouse double minute 2 human homolog (MDM2), and cyclin dependent kinase inhibitor 2A (ARF) using immunohistochemical analyses. All samples were analyzed for TP53R175H and TP53R273H. Results: CD24, mutant p53, MDM2, and ARF proteins were expressed in 55%, 24%, 39%, and 68% of prostate cancer samples, respectively. CD24 and mutant p53 were present more frequently in late-stage and metastatic prostate cancer. The presence of CD24 was associated with a greater than fourfold risk of metastasis, which included lymph node and distant metastases. H score analysis showed positive correlations of CD24 expression with mutant p53 (r =.308, P <.001) and MDM2 (r =.227, P =.004). There was a negative correlation for CD24 with ARF (r = −.280, P <.001). A racial disparity was evident for CD24 (AAs/EAs: 64% vs 47%; P =.004) but not for mutant p53 (AA/EA: 28% vs 21%; P =.152). In 32 CD24+/mutant p53+ cases, a TP53R273H mutation was found in five cases, but no TP53R175H mutation was found. Conclusion: The CD24-p53 axis may contribute to aggressive and metastatic prostate cancers, especially those of AAs. This observation enhances understanding of the pathogenesis of prostate cancer and its associated racial disparities.","journal":"UNC Libraries","year":2023,"id":410440,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107375,"name":"Elizabeth T. H. Fontham","orcid":null,"position":1,"is_corresponding":false},{"id":294036,"name":"James L. Mohler","orcid":"0000-0002-7726-3795","position":2,"is_corresponding":false},{"id":1190456,"name":"Ran Liu","orcid":"0000-0002-9605-231X","position":3,"is_corresponding":false},{"id":683443,"name":"Kun Zhang","orcid":"0000-0001-8915-1769","position":4,"is_corresponding":false},{"id":364089,"name":"Wei Liu","orcid":"0000-0003-0935-3999","position":5,"is_corresponding":false},{"id":1017919,"name":"Lei Wang","orcid":"0000-0003-2402-2338","position":6,"is_corresponding":false},{"id":367198,"name":"Gary J. Smith","orcid":"0000-0003-1187-4849","position":7,"is_corresponding":false},{"id":834175,"name":"Wenhui Yang","orcid":"0000-0001-8836-0278","position":8,"is_corresponding":false},{"id":274683,"name":"Guru Sonpavde","orcid":"0000-0002-1010-9611","position":9,"is_corresponding":false},{"id":367196,"name":"Jeannette T. Bensen","orcid":"0000-0003-4972-0087","position":10,"is_corresponding":false},{"id":348105,"name":"Sejong Bae","orcid":"0000-0001-9982-3223","position":11,"is_corresponding":false},{"id":1190457,"name":"G.-Y. Chen","orcid":"0009-0009-2614-4751","position":12,"is_corresponding":false},{"id":1190455,"name":"Shuzhen Wei","orcid":"0000-0001-7804-1548","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:35.071397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}