{"doi":"10.17615/whxm-cn78","title":"Genetic architecture of voluntary exercise in an advanced intercross line of mice","abstract":"Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in is strikingly variable, even under prescription. Our focus was to identify the locations and effects of quantitative trait loci (QTL) controlling genetic predisposition for exercise-related traits utilizing a large advanced intercross line (AIL) of mice. This AIL (G4) population originated from a reciprocal cross between mice with genetic propensity for increased voluntary exercise (HR, selectively bred for increased wheel running) and the inbred strain C57BL/6J. After adjusting for family structure, we detected 32 significant and 13 suggestive QTL representing both daily running traits (distance, duration, average speed, and maximum speed) and the mean of these traits on days 5 and 6 (the selection criteria for HR) of a 6-day test conducted at 8 weeks of age, with many colocalizing to similar genomic regions. Additionally, 7 significant and 5 suggestive QTL were observed for the slope and intercept of a linear regression across all 6 days of running, some representing a combination of the daily traits. We also observed 2 significant and 2 suggestive QTL for body mass prior to exercise. These results, using a well-defined animal model, reinforce a genetic basis for the predisposition to engage in voluntary exercise, dissect this predisposition into daily segments across a continuous time period, and present unique QTL that may provide insight into the initiation, continuation, and temporal pattern of voluntary activity in mammals.","journal":"UNC Libraries","year":2021,"id":230633,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7992,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":525870,"name":"Theodore Garland","orcid":"0000-0002-7916-3552","position":1,"is_corresponding":false},{"id":837430,"name":"Scott Kelly","orcid":null,"position":2,"is_corresponding":false},{"id":210203,"name":"Daniel Pomp","orcid":null,"position":3,"is_corresponding":false},{"id":436873,"name":"Kunjie Hua","orcid":null,"position":4,"is_corresponding":false},{"id":837431,"name":"Jeremy L. Peirce","orcid":null,"position":5,"is_corresponding":false},{"id":541383,"name":"Derrick L. Nehrenberg","orcid":null,"position":6,"is_corresponding":false},{"id":591984,"name":"Tim Wiltshire","orcid":"0000-0001-5960-4034","position":7,"is_corresponding":false},{"id":837432,"name":"Brian D. Steffy","orcid":null,"position":8,"is_corresponding":false},{"id":275088,"name":"Fernando Pardo‐Manuel de Villena","orcid":"0000-0002-5738-5795","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:09.211909Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}